AGI25696-Analog

• CAS: 2201066-35-3
• Catalog Number: ACM2201066353
• Category: Inhibitors
• Molecular Weight: 414.47
• Molecular Formula: C27H18N4O
• Description: AGI25696-Analog is a demethyl analog of AGI-25696, which is a methionine adenosyltransferase 2A (MATA2 ) inhibitor. AGI-25696 is potentially useful for treatment of cancer. AGI-25696 blocks growth of MTAP-deleted tumors in vivo. Note: The correct structure of AGI-25696 is CAS#2201065-84-9. Many vendors mistakenly listed CAS#2201066-35-3 as its AGI25696. J. Med. Chem. 2021, 64, 8, 4430-4449 published AGI25696 structure (it is CAS#2201065-84-9).
• Synonyms: AGI25696-Analog, AGI-25696-demethyl; AGI 25696-demethyl; AGI25696-demethyl
• IUPAC Name: 2,3-diphenyl-6-(quinolin-6-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
• Canonical SMILES: O=C1C(C2=CC=C3N=CC=CC3=C2)=CNC4=C(C5=CC=CC=C5)C(C6=CC=CC=C6)=NN14
• InChI: InChI=1S/C27H18N4O/c32-27-22(20-13-14-23-21(16-20)12-7-15-28-23)17-29-26-24(18-8-3-1-4-9-18)25(30-31(26)27)19-10-5-2-6-11-19/h1-17,29H
• InChI Key: VJMSOWXHWUORTA-UHFFFAOYSA-N
• Solubility: To be determined
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Alternative CAS: 2201066-35-3 (de-methyl); 2201065-84-9
• Drug Formulation: To be determined
• Elemental Analysis: C, 78.24; H, 4.38; N, 13.52; O, 3.86
• Exact Mass: 414.1481
• HS Tariff Code: 2934.99.9001
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).