Aluminum Hydroxide Nanoparticles

• CAS: 21645-51-2
• Catalog Number: ACM21645512-35
• Category: Main Products
• Molecular Weight: 78
• Molecular Formula: Al(OH)3
• Synonyms: Aluminium hydrate
• IUPAC Name: aluminum trihydroxide
• Canonical SMILES: [OH-].[OH-].[OH-].[Al+3]
• InChI: InChI=1S/Al.3H₂O/h;3*1H2/q+3;;;/p-3
• InChI Key: WNROFYMDJYEPJX-UHFFFAOYSA-K
• Melting Point: 300° C (572° F)
• Density: 2.4
• Appearance: white powder
• Chemical Formula: H3AIO3
• EC Number: 244-492-7
• Exact Mass: 77.989757
• Hazard Codes: Xi
• Hazard Statements: H319
• MDL Number: MFCD00003420
• Monoisotopic Mass: 77.989757
• Risk Codes: 36
• RTECS Number: BD0940000
• Safety Description: 26-36
• Stability: Stable. Incompatible with strong bases.
• WGK Germany: -

Case Study

Aluminum Hydroxide Nanoparticles as a Novel Adjuvant Delivery System for Enhancing Immune Stimulation in Vaccine Development

Gu P, et al. International Journal of Biological Macromolecules, 2024, 281(1), 135914.

The immune stimulant Chinese yam polysaccharide (CYP) was loaded onto aluminum nanoparticles (Al NPs) to create a novel adjuvant delivery system (CYP-Al NPs).
The preparation method for aluminum hydroxide nanoparticles (Al NPs) is as follows: To obtain CYP-Al NPs, 40 mg of Al NPs solution and 4 mg of CYP solution were mixed in 10 mL of solution and subjected to ultrasonic treatment under an ice bath until fully dissolved. The mixture was then shaken for 2 hours at room temperature and incubated overnight at 4°C.
For the preparation of OVA-loaded nanoparticle vaccines, Al NPs and CYP-Al NPs formulations were separately mixed with 200 μg/mL OVA solution at a 1:1 (v/v) ratio. After shaking for 2 hours, the OVA-loaded nanoparticle vaccines were stored overnight at 4°C. Similarly, aluminum hydroxide gel adjuvant was mixed with the OVA solution in the same amount, shaken for 2 hours, and stored overnight at 4°C.

Aluminum Hydroxide Nanoparticles for Stabilizing Fluorine-Free Firefighting Foams: Enhancing Rheology and Foam Stability

Zhang S, et al. Journal of Molecular Liquids, 2024, 401, 124627.

Recent studies demonstrate that aluminum hydroxide nanoparticles (Al(OH)3 NPs) significantly enhance the rheological properties, stability, and thixotropy of foam formulations. When incorporated into foam mixtures, Al(OH)₃ NPs impart shear thinning behavior, improving foamability and viscosity while enhancing the foam's stability. The presence of Al(OH)3 NPs increases both the viscoelasticity and thixotropic recovery of the foam, with higher concentrations of nanoparticles resulting in stronger foam structures and slower deformation recovery, thereby improving foam performance. This nanoparticle-stabilized foam exhibits a wide linear viscoelastic range and delayed flow points, making it more effective in firefighting applications.

Aluminum Hydroxide Nanoparticles for Enhancing Soybean Meal Strong Binders

Bian Y, et al. International Journal of Adhesion and Adhesives, 2023, 125, 103442.

This study, inspired by the nacre and byssus of mussels, introduces Al(OH)₃ nanoparticles into soybean meal adhesives, forming a novel organic-inorganic hybrid system. The interaction between Al(OH)₃ nanoparticles and soybean meal results in the formation of a dense, non-covalent crosslinked network based on hydrogen bonding and coordination bonds, which enhances the adhesive performance and water resistance of the soybean meal adhesive.
Synthesis of Nano-Al(OH)3 Modified Soybean Adhesive
A solution of Al(OH)₃ nanoparticles with varying concentrations (6%) is added to deionized water, stirred to ensure uniform dispersion of the aluminum hydroxide. Then, tris(hydroxymethyl)aminomethane (TGA) is added as a chemical crosslinking agent. Soybean meal (SM) is incorporated into the solution and stirred for 30 minutes to obtain the SM/Al adhesive.