SKF89976A

CAS

85375-15-1

Catalog Number

ACM85375151-1

Category

Inhibitors

Molecular Weight

335.45

Molecular Formula

C22H25NO2

MSDS COA Spec Sheet

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Specification

Description

SKF89976A is a potent GABA uptake inhibitor, which is selective for GAT-1 (IC50 values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). SKF89976A inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). It is able to pass the blood-brain barrier after systemic administration and is active in vivo.

Synonyms

SKF89976A; SKF 89976A; SKF-89976A

IUPAC Name

1-(4,4-diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid

Canonical SMILES

O=C(C1CN(CC/C=C(C2=CC=CC=C2)/C3=CC=CC=C3)CCC1)O

InChI

InChI=1S/C22H25NO2/c24-22(25)20-13-7-15-23(17-20)16-8-14-21(18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-6,9-12,14,20H,7-8,13,15-17H2,(H,24,25)

InChI Key

TXQKSMSLZVKQBI-UHFFFAOYSA-N

Solubility

Soluble in DMSO

Appearance

Solid powder

Shelf Life

>2 years if stored properly

Storage

Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).

Alternative CAS

85375-15-1 ( free base); 85375-85-5 (HCl)

Drug Formulation

This drug may be formulated in DMSO

Elemental Analysis

C, 78.77; H, 7.51; N, 4.18; O, 9.54

Exact Mass

335.1885

HS Tariff Code

2934.99.9001

Shipping

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Stock Solution Storage

0-4 °C for short term (days to weeks), or -20 °C for long term (months).