Original Article:
Risks in clinical applications of oseltamivir phosphate in the real world
Lei Zheng, et al.
Die Pharmazie-An International Journal of Pharmaceutical Sciences, 2020, 75(6): 284-287.
10.1691/ph.2020.0352
Oseltamivir phosphate, an oral neuraminidase inhibitor, is currently the preferred antiviral drug recommended in influenza treatment guidelines and expert consensus. Oseltamivir phosphate is a competitive inhibitor of influenza neuraminidase. The enzyme cleaves sialic acid, which is found on glycoproteins on the surface of human cells and helps new virus particles leave the cell. Thus, oseltamivir prevents new viral particles from being released.
On the one hand, this article reviews the therapeutic use of oseltamivir phosphate. Oseltamivir phosphate is mainly used as a therapeutic drug for upper respiratory tract infection, bronchitis and pneumonia. Oseltamivir phosphate is mainly used as a preventive drug for fever, abdominal pain, osteoarthritis, rhinitis, interstitial pneumonia, hypertension, mumps, and cough. The author pointed out that there are many problems with preventive medication, that is, oseltamivir phosphate is effective against influenza virus, but it is not suitable for common cold, herpes virus, Epstein-Barr virus, adenovirus, human cytomegalovirus and other viruses.
On the other hand, this article also summarizes the risks of oseltamivir phosphate in clinical use. The main types of adverse reactions caused by oseltamivir phosphate are mainly digestive system reactions such as nausea and vomiting, followed by central nervous system reactions.
Note: Medical content is for informational purposes only and should not be considered professional advice. For medical help or advice, consult a professional.
Chemicals Related in the Paper:
| Catalog Number | Product Name | Structure | CAS Number | Price |
|---|---|---|---|---|
| ACM204255118 | Oseltamivir Phosphate |  |
204255-11-8 | Price |
