Oseltamivir Phosphate

• CAS: 204255-11-8
• Catalog Number: ACM204255118
• Category: Inhibitors
• Molecular Weight: 410.40
• Molecular Formula: C₁₆H₃₁N₂O₈P
• Description: Oseltamivir phosphate (GS 4104) is a neuraminidase inhibitor recommended for the treatment and prophylaxis of influenza A and B.
• Synonyms: OseltaMivir Acid-D3 Phosphate; Osteltamivir phosphate; Oseltamir phosphate; Oseltamivir phosphate; Oseltamivir Phosphate; Oseltamivir phosphat; Oselt; NTERMEDIATES OF OSELTAMIVIR
• IUPAC Name: ethyl(3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylate;phosphoricacid
• Canonical SMILES: CCC(CC)OC1C=C(CC(C1NC(=O)C)N)C(=O)OCC.OP(=O)(O)O
• InChI Key: PGZUMBJQJWIWGJ-ONAKXNSWSA-N
• Boiling Point: 473.3ºC at 760 mmHg
• Flash Point: 240ºC
• Density: 1.08g/cm³
• Appearance: white cyrstalline solid
• Application: Used for anti-influenza virus
• Storage: 4°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture).
• Assay: 98.5%-102.0%
• Exact Mass: 410.18200
• Related Substances: lmpurity C≤0.2%, impurity D≤0.1%, impurity G≤0.1%, single impurity≤0.1%, the sum of single impurities≤0.4%, total impurity≤0.5%
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Storage Conditions: ≤30 °C, preserve in tight containers from light
• Water Content: Not more than 0.5%

Synthetic Use

Upstream Synthesis Route 1

• 204254-96-6

• 204255-11-8

Reference: [1]Rohloff, John C.; Kent, Kenneth M.; Postich, Michael J.; Becker, Mark W.; Chapman, Harlan H.; Kelly, Daphne E.; Lew, Willard; Louie, Michael S.; McGee, Lawrence R.; Prisbe, Ernest J.; Schultze, Lisa M.; Yu, Richard H.; Zhang, Lijun
[Journal of Organic Chemistry, 1998, vol. 63, # 13, p. 4545 - 4547]
[2]Nie, Liang-Deng; Wang, Fei-Feng; Ding, Wei; Shi, Xiao-Xin; Lu, Xia
[Tetrahedron Asymmetry, 2013, vol. 24, # 11, p. 638 - 642]
[3]Current Patent Assignee: TOHO UNIVERSITY - US2014/51756, 2014, A1
[4]Current Patent Assignee: SHANGHAI AOBO PHARMTECH; ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. - CN113024396, 2021, A

Upstream Synthesis Route 2

• 196618-13-0

• 204255-11-8

Reference: [1]Patent: US2004/180933,2004,A1 .Location in patent: Page/Page column 11

Upstream Synthesis Route 3

• 367252-68-4

• 204255-11-8

Reference: [1]Journal of the American Chemical Society,2018,vol. 140,p. 10619 - 10626