Zinc pyrithione

• CAS: 13463-41-7
• Catalog Number: ACM13463417-2
• Category: Inhibitors
• Molecular Weight: 317.40
• Molecular Formula: C10H8N2O2S2Zn
• Description: Pyrithione zinc, also commonly known as zinc pyrithione, has antibacterial, antimicrobial, and antifungal properties that can help treat seborrheic dermatitis (also called dandruff), scalp psoriasis, and acne.
• Synonyms: ZPT
• IUPAC Name: Zinc;1-oxidopyridin-1-ium-2-thiolate
• Canonical SMILES: C1=CC=[N+](C(=C1)[S-])[O-].C1=CC=[N+](C(=C1)[S-])[O-].[Zn+2]
• InChI: InChI=1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4,8H;/q;+2/p-2
• InChI Key: OTPSWLRZXRHDNX-UHFFFAOYSA-L
• Melting Point: 240 ℃
• Density: 1.782 g/cm3
• Solubility: insoluble (<0.1 g/100 mL at 21 ºC)
• Appearance: White to slight yellow powder or white suspension
• Application: ZPT-50 is the most important antidandruf agent in the world, which used for more than 30 years in shampoo. ZPT-50 shows excellent inhibiting effect on pytyrosporum ovale that causes dandruff. ZPT has broad spectrum bactericide and marine antifouling material, and is well used for cosmetic, shampoo, skins medicine, adhesive and coating painting and so on.
• Storage: Content is unchanged in two years.
• Active Content: 95%
• Assay: 96.0%min
• Complexity: 183
• Covalently-Bonded Unit Count: 3
• Defined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• EC Number: 236-671-3
• Exact Mass: 315.931862
• Formal Charge: 0
• Heavy Atom Count: 17
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 0
• Isotope Atom Count: 0
• Loss On Drying: 0.5%
• Monoisotopic Mass: 315.931862
• Packaging: In 25 kgs net plastic drum (solution), 25 kgs net cardboard drum (powder) .
• pH: 6.5-8.5 (5% solution)
• Physical State: Off-white Powder
• Rotatable Bond Count: 2
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Stability: Stable under ordinary conditions
• Storage Conditions: Store in a cool and dry ventilated place.
• Topological Polar Surface Area: 52.9 Ų
• Undefined Atom Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0

Custom Q&A

What is the chemical formula of Zinc pyrithione?

The chemical formula of Zinc pyrithione is C10H8N2O2S2Zn.

What is the melting point of Zinc pyrithione?

The melting point of Zinc pyrithione is approximately 240°C.

What is the water solubility of Zinc pyrithione?

Zinc pyrithione is insoluble in water (<0.1 g/100 mL at 21°C).

How is Zinc pyrithione described in terms of odor?

Zinc pyrithione is described as having a mild characteristic odor.

What are the safety hazards associated with Zinc pyrithione?

Zinc pyrithione is classified as a T+, N, and T hazard according to hazard codes.

What is the primary use of Zinc pyrithione in cosmetics?

Zinc pyrithione is used as an antifungal, antibacterial, and antiseborrheic agent in shampoos and hair creams.

What is the role of Zinc pyrithione in pharmaceutical applications?

Zinc pyrithione is a regulator of keratinization and has antimicrobial properties, making it effective in treating conditions like dandruff.

How does Zinc pyrithione react with surfactants?

Zinc pyrithione reacts with cationic and non-ionic surfactants, forming insoluble precipitates.

What are the toxicity evaluations of Zinc pyrithione on aquatic organisms?

Zinc pyrithione is toxic to aquatic organisms, with L(E)C50 values in the range of 3-300 µg/L.

What is the recommended concentration of Zinc pyrithione in cosmetics according to EEC and GB7916-87?

The maximum allowable concentration of Zinc pyrithione in cosmetics is 0.5%, with a general concentration range of 250-1000 mg/kg.

Synthetic Use

Upstream Synthesis Route 1

• 15922-78-8
• 7646-85-7

• 13463-41-7

Reference: [1] Patent: EP1695963, 2006, A1, . Location in patent: Page/Page column 4-5

Upstream Synthesis Route 2

• 100685-55-0
• 15922-78-8

• 13463-41-7

Reference: [1] Patent: US6432432, 2002, B1,

Upstream Synthesis Route 3

• 15922-78-8

• 13463-41-7

Reference: [1] Journal of Physics and Chemistry of Solids, 2006, vol. 67, # 5-6, p. 1071 - 1074

Upstream Synthesis Route 4

• 3811-73-2
• 7646-85-7

• 13463-41-7

Reference: [1]Current Patent Assignee: KOLON INDUSTRIES INC. - EP1695963, 2006, A1
Location in patent: Page/Page column 4-5

Upstream Synthesis Route 5

• 100685-55-0
• 3811-73-2

• 13463-41-7

Reference: [1]Current Patent Assignee: LONZA GROUP AG - US6432432, 2002, B1
[2]Current Patent Assignee: LONZA GROUP AG - US6017562, 2000, A