Scutellarin

• CAS: 27740-01-8
• Catalog Number: ACM27740018
• Category: Inhibitors
• Molecular Weight: 462.36
• Molecular Formula: C21H18O12
• Description: Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC50s of 26 μM, 253 μM and 136 μM, respectively.
• Synonyms: 4',5,6,7-Tetrahydroxyflavone 7-β-D-glucopyranuronoside
• IUPAC Name: (2S,3S,4S,5R,6S)-6-[5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
• Canonical SMILES: C1=CC(=CC=C1C2=CC(=O)C3=C(C(=C(C=C3O2)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C(=O)O)O)O)O)O)O)O
• InChI: InChI=1S/C21H18O12/c22-8-3-1-7(2-4-8)10-5-9(23)13-11(31-10)6-12(14(24)15(13)25)32-21-18(28)16(26)17(27)19(33-21)20(29)30/h1-6,16-19,21-22,24-28H,(H,29,30)/t16-,17-,18+,19-,21+/m0/s1
• InChI Key: DJSISFGPUUYILV-ZFORQUDYSA-N
• Boiling Point: 891.6±65.0 °C
• Melting Point: 300-301 °C
• Density: 1.810±0.06 g/ml
• Appearance: Yellow powder
• pKa: 2.72±0.70

Synthetic Use

Upstream Synthesis Route 1

• 119262-68-9

• 27740-01-8

Reference: [1] Patent: EP2840088, 2015, A1, . Location in patent: Paragraph 0042

Upstream Synthesis Route 2

• 529-53-3

• 27740-01-8

Reference: [1] Patent: EP2840088, 2015, A1,

Upstream Synthesis Route 3

• 1180-46-7

• 27740-01-8

Reference: [1] Patent: EP2840088, 2015, A1,