Xestospongin c

• CAS: 88903-69-9
• Catalog Number: ACM88903699
• Category: Inhibitors
• Molecular Weight: 446.71
• Molecular Formula: C₂₈H₅₀N₂O₂
• Description: Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca2+ release from cerebellar microsomes with an IC50 of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca2+ signaling in neuronal and nonneuronal cells.
• Synonyms: [1R-(1R*,4AR*,11R*,12AS*,13S*,16AS*,23R*,24AS*)]-EICOSAHYDRO-5H,17H-1,23:11,13-DIETHANO-2H,14H-[1,11]DIOXACYCLOEICOSINO[2,3-B:12,13-B]DIPYRIDINE; (1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,
• IUPAC Name: XESTOSPONGIN C
• Boiling Point: 564.694ºC at 760 mmHg
• Flash Point: 145.63ºC
• Density: 1.06g/cm³
• Appearance: off-white
• Exact Mass: 446.38700