Wedelolactone

• CAS: 524-12-9
• Catalog Number: ACM524129
• Category: Inhibitors
• Molecular Weight: 314.25
• Molecular Formula: C16H10O7
• Description: Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC50 of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer.
• Synonyms: Pentafluorobenzaldehyde
• Canonical SMILES: COC1=CC(=C2C(=C1)OC(=O)C3=C2OC4=CC(=C(C=C43)O)O)O

Synthetic Use

Upstream Synthesis Route 1

• 67964-24-3
• 120-80-9

• 524-12-9

Reference: [1]Wong; Antus; Gottsegen; Fessler; Rao; Sonnenbichler; Wagner
[Arzneimittel-Forschung/Drug Research, 1988, vol. 38, # 5, p. 661 - 665]
[2]Pandey, G.; Muralikrishna, C.; Bhalerao, U. T.
[Tetrahedron, 1989, vol. 45, p. 6867 - 6874]

Upstream Synthesis Route 2

• 115623-32-0

• 524-12-9

Reference: [1]Wong; Antus; Gottsegen; Fessler; Rao; Sonnenbichler; Wagner
[Arzneimittel-Forschung/Drug Research, 1988, vol. 38, # 5, p. 661 - 665]
[2]Huang, Huidan; Chen, Jianqiu; Ren, Jie; Zhang, Chaofeng; Ji, Fei
[Molecules, 2019, vol. 24, # 22]

Downstream Synthesis Route 1

• 524-12-9
• 100-44-7

• 115623-32-0

Reference: [1]Wong; Antus; Gottsegen; Fessler; Rao; Sonnenbichler; Wagner
[Arzneimittel-Forschung/Drug Research, 1988, vol. 38, # 5, p. 661 - 665]

* For details of the synthesis route, please refer to the original source to ensure accuracy.