Apocynin

• CAS: 498-02-2
• Catalog Number: ACM498022
• Category: Inhibitors
• Molecular Weight: 166.17
• Molecular Formula: C9H10O3
• Description: Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM.
• Synonyms: Acetovanillone
• Canonical SMILES: CC(C1=CC=C(O)C(OC)=C1)=O
• Appearance: Solid
• Storage: Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Source: PlantsOrchidaceaeAnoectochilus roxburghii (Wall.) Lindl.

Synthetic Use

Upstream Synthesis Route 1

• 613-70-7

• 498-02-2

Reference: [1]Current Patent Assignee: YANCHENG JINMING PHARMACEUTICAL; YANCHENG TEACHERS UNIVERSITY - CN110903178, 2020, A
Location in patent: Paragraph 0050-0079

Downstream Synthesis Route 1

• 100-39-0
• 498-02-2

• 1835-11-6

Reference: [1] Patent: WO2005/30140, 2005, A2, . Location in patent: Page/Page column 198

Downstream Synthesis Route 2

• 77-78-1
• 498-02-2

• 1835-11-6

Reference: [1] European Journal of Medicinal Chemistry, 2012, vol. 48, p. 371 - 378

Downstream Synthesis Route 3

• 100-44-7
• 498-02-2

• 1835-11-6

Reference: [1] European Journal of Organic Chemistry, 2018, vol. 2018, # 42, p. 5843 - 5852

Downstream Synthesis Route 4

• 106-95-6
• 498-02-2

• 116218-80-5

Reference: [1]Dettori, Maria Antonietta; Fabbri, Davide; Dessì, Alessandro; Dallocchio, Roberto; Carta, Paola; Honisch, Claudia; Ruzza, Paolo; Farina, Donatella; Migheli, Rossana; Serra, Pier Andrea; Pantaleoni, Roberto A.; Fois, Xenia; Rocchitta, Gaia; Delogu, Giovanna
[Molecules, 2020, vol. 25, # 11]
[2]Kratzl; Daeubner
[Chemische Berichte, 1944, vol. 77/79, p. 519,526]

* For details of the synthesis route, please refer to the original source to ensure accuracy.