VU0463597

• CAS: 1382481-79-9
• Catalog Number: ACM1382481799
• Category: Others
• Molecular Weight: 349.43
• Molecular Formula: C22H23NO3
• Description: VU0463597, also known as ML-289, is a negative allosteric modulator of mGlu3 (IC50 = 0.66 μM) that displays 15-fold selectivity over mGlu2 and inactivity against mGlu5.1.
• Synonyms: VU0463597, VU 0463597, VU-0463597, ML-289, ML 289; ML289
• IUPAC Name: [(3R)-1-({4-[2-(4-methoxyphenyl)ethynyl]phenyl}carbonyl)piperidin-3-yl]methanol
• Canonical SMILES: OC[C@H]1CN(C(C2=CC=C(C#CC3=CC=C(OC)C=C3)C=C2)=O)CCC1
• InChI: InChI=1S/C22H23NO3/c1-26-21-12-8-18(9-13-21)5-4-17-6-10-20(11-7-17)22(25)23-14-2-3-19(15-23)16-24/h6-13,19,24H,2-3,14-16H2,1H3/t19-/m1/s1
• InChI Key: VSLWUPHHCFQTDB-LJQANCHMSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 75.62; H, 6.63; N, 4.01; O, 13.74
• Exact Mass: 349.1678
• HS Tariff Code: 2934.99.9001
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).