Valganciclovir hydrochloride

• CAS: 175865-59-5
• Catalog Number: ACM175865595
• Category: Inhibitors
• Molecular Weight: 390.82
• Molecular Formula: C₁₄H₂₃ClN₆O₅
• Description: Valganciclovir (hydrochloride), the L-valyl ester of ganciclovir, is actually a prodrug for ganciclovir. Valganciclovir is an antiviral medication used to treat cytomegalovirus infections.IC50 Value:Target: CMVin vitro: In cell culture model systems using Caco-2 cells for PEPT1 and SKPT cells for PEPT2, valganciclovir inhibited glycylsarcosine transport mediated by PEPT1 and PEPT2 with K(i) values (inhibition constant) of 1.68+/-0.30 and 0.043+/- 0.005 mM, respectively. The inhibition by valganciclovir was competitive in both cases .in vivo: 37 patients were enrolled; 19 patients received treatment with VGV and 18 patients received treatment with GCV. The VGV was not inferior in efficacy to GCV as pre-emptive therapy, with rates of viral clearance at 28 days of 89.5% and 83%, respectively (P-value for non-inferiority = 0.030). Toxicities were similar between the 2 arms. No patients developed CMV disease . Patients being treated with an alemtuzumab-containing regimen received prophylaxis with either valaciclovir 500 mg orally daily orvalganciclovir 450 mg orally twice daily. None of the 20 patients randomized to valganciclovir experienced CMV reactivation (P = .004) .
• Synonyms: VALGANCICLOVIR HYDROCHLORIDE;L-VALINE, 2-[(2-AMINO-1,6-DIHYDRO-6-OXO-9H-PURIN-9-YL)METHOXY]-3-HYDROXYPROPYL ESTER, MONOHYDROCHLORIDE;VALGANCICLOVIR HCL;L-VALINE,2-[(2-AMINO-1,6-DIHYDRO-6-OXO-9H-PURIN-9-YL)METHOXY]-3-HYDROXYPROPYLESTER,MONOHYDROCHLORIDE;Ro 107-9070/194;Rs 079070-194;Unii-4p3T9qf9nz;Valcyt
• Canonical SMILES: N[C@@H](C(C)C)C(OCC(OCN1C=NC2=C1N=C(N)NC2=O)CO)=O.[H]Cl
• Melting Point: 162-164°C
• Appearance: Solid
• Storage: 4°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture).
• Shipping: Can be shipped at room temperature, where not in use may vary.

Custom Q&A

What is the molecular formula of Valganciclovir hydrochloride?

The molecular formula of Valganciclovir hydrochloride is C14H23ClN6O5.

What is the molecular weight of Valganciclovir hydrochloride?

The molecular weight of Valganciclovir hydrochloride is 390.82 g/mol.

What is Valganciclovir hydrochloride used for?

Valganciclovir hydrochloride is an antiviral prescription medicine approved for the treatment of cytomegalovirus retinitis in adults with AIDS and for the prevention of CMV disease in organ transplant recipients.

What is the prodrug form of Valganciclovir hydrochloride?

Valganciclovir is the prodrug form of ganciclovir.

How is Valganciclovir hydrochloride incorporated into DNA to inhibit viral replication?

After phosphorylation, Valganciclovir is incorporated into DNA, resulting in inhibition of viral DNA polymerase and viral replication.

What are some synonyms for Valganciclovir hydrochloride?

Some synonyms for Valganciclovir hydrochloride include Valcyte and Valcyt.

What is the CAS number of Valganciclovir hydrochloride?

The CAS number of Valganciclovir hydrochloride is 175865-59-5.

How many hydrogen bond donor counts are in Valganciclovir hydrochloride?

Valganciclovir hydrochloride has 5 hydrogen bond donor counts.

What is the InChIKey of Valganciclovir hydrochloride?

The InChIKey of Valganciclovir hydrochloride is ZORWARFPXPVJLW-MTFPJWTKSA-N.

What is the European Community (EC) Number of Valganciclovir hydrochloride?

The European Community (EC) Number of Valganciclovir hydrochloride is 641-360-4.