Tulathromycin A

• CAS: 217500-96-4
• Catalog Number: ACM217500964
• Category: Others
• Molecular Weight: 806.09
• Molecular Formula: C41H79N3O12
• Description: Tulathromycin A, also known as Tulathromycin and CP-472295, is a macrolide antibiotic used to treat bovine respiratory disease (BRD) in cattle and swine respiratory disease in pigs.
• Synonyms: Tulathromycin; Draxxin; Tulathromycin A; CP-472,295; CP-472295; CP 472295; CP472295
• IUPAC Name: (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-5-(propylaminomethyl)oxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one
• Canonical SMILES: O=C1[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@](CNCCC)(O)[C@](C)(OC)C2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)O1
• InChI: InChI=1S/C41H79N3O12/c1-15-17-42-22-41(50)28(8)53-31(20-39(41,10)51-14)55-33-25(5)35(56-37-32(45)29(44(12)13)18-24(4)52-37)38(9,48)19-23(3)21-43-27(7)34(46)40(11,49)30(16-2)54-36(47)26(33)6/h23-35,37,42-43,45-46,48-50H,15-22H2,1-14H3/t23-,24-,25+,26-,27-,28+,29+,30-,31+,32-,33+,34-,35-,37+,38-,39-,40-,41+/m1/s1
• InChI Key: GUARTUJKFNAVIK-QPTWMBCESA-N
• Density: 1.17
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: Tulathromycin A (Tulathromycin), a macrolide antibiotic, inhibits protein synthesis (IC50=0.26 µM) by targeting bacterial ribosome.
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 61.09; H, 9.88; N, 5.21; O, 23.82
• Exact Mass: 805.5664
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: The immunomodulating mechanisms of the TUL activities were further analyzed in bovine cells in vitro. Tulathromycin inhibited the release of free fatty acids in bovine neutrophils stimulated with 10 μM melittin, an activator of PLA2. Furthermore, in both resting neutrophils and in those stimulated with 3 μM A23187, tulathromycin significantly reduced secreted levels of LTB4. The addition of 3 μM exogenous arachidonic acid partially restored the levels of LTB4 in tulathromycin-treated neutrophils.; Reference: Antimicrob Agents Chemother. 2014 Aug;58(8):4298-307. https://pubmed.ncbi.nlm.nih.gov/24820086/
• In Vivo Activity: To investigate the direct anti-inflammatory actions of tulathromycin in the absence of a bacterial stimulus, calves were challenged intratracheally with zymosan, a known Toll-like receptor 2 (TLR2) ligand that has been used as an inflammatory stimulus in vivo. Three hours postchallenge, BAL fluid LTB4 levels were significantly higher in zymosan-challenged sham-treated calves than in control calves (mean ± standard deviation, 209.9 ± 60.5 pg/ml and 51.1 ± 13.1 pg/ml, respectively); tulathromycin abolished this increase in BAL fluid LTB4 levels (63.9 ± 16.0 pg/ml). Twenty-four hours postchallenge, the BAL fluid levels of PGE2 were significantly higher in calves challenged with zymosan versus in the controls (594.6 ± 134.5 pg/ml and 142.5 ± 59.2 pg/ml, respectively); tulathromycin treatment inhibited the increase in BAL fluid PGE2 levels caused by zymosan (148.3 ± 34.7 pg/ml).; Reference: Antimicrob Agents Chemother. 2014 Aug;58(8):4298-307. https://pubmed.ncbi.nlm.nih.gov/24820086/
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).

Custom Q&A

What is the molecular formula of Tulathromycin?

The molecular formula of Tulathromycin is C41H79N3O12.

What is the molecular weight of Tulathromycin?

The molecular weight of Tulathromycin is 806.1 g/mol.

What is the IUPAC name of Tulathromycin?

The IUPAC name of Tulathromycin is (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-5-(propylaminomethyl)oxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one.

What is the InChIKey of Tulathromycin?

The InChIKey of Tulathromycin is GUARTUJKFNAVIK-QPTWMBCESA-N.

What is the CAS number of Tulathromycin?

The CAS number of Tulathromycin is 217500-96-4.

How many hydrogen bond donor counts does Tulathromycin have?

Tulathromycin has 7 hydrogen bond donor counts.

How many hydrogen bond acceptor counts does Tulathromycin have?

Tulathromycin has 15 hydrogen bond acceptor counts.

How many rotatable bond counts does Tulathromycin have?

Tulathromycin has 11 rotatable bond counts.

What is the exact mass of Tulathromycin?

The exact mass of Tulathromycin is 805.56637496 g/mol.

What is the topological polar surface area of Tulathromycin?

The topological polar surface area of Tulathromycin is 201.2.