Trovafloxacin

• CAS: 147059-72-1
• Catalog Number: ACM147059721
• Category: Inhibitors
• Molecular Weight: 416.35
• Molecular Formula: C₂₀H₁₅F₃N₄O₃
• Description: Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current. Trovafloxacin does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1.
• Synonyms: TROVAFLOXACIN;1,8-Naphthyridine-3-carboxylic acid, 7-(1.alpha.,5.alpha.,6.alpha.)-6-amino-3-azabicyclo3.1.0hex-3-yl-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-;(1α,5α,6α)-7-(6-Amino-3-azabi-cyclo[3.1.0]hex-3-y1)-1-(2,4-difluomphenyl)-6-fluom-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid;CP-99219;Trovan:CP-99219-27;7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-keto-1,8-naphthyridine-3-carboxylic acid;7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid;7-[(1R,5S)-6-azanyl-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Custom Q&A

What is the molecular formula of trovafloxacin?

The molecular formula of trovafloxacin is C20H15F3N4O3.

What is the molecular weight of trovafloxacin?

The molecular weight of trovafloxacin is 416.4 g/mol.

What is the Synonym of trovafloxacin?

The synonym of trovafloxacin is Trovafloxacin.

What is the IUPAC name of trovafloxacin?

The IUPAC name of trovafloxacin is 7-[(1S,5R)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid.

What is the InChIKey of trovafloxacin?

The InChIKey of trovafloxacin is WVPSKSLAZQPAKQ-SOSAQKQKSA-N.

What is the CAS number of trovafloxacin?

The CAS number of trovafloxacin is 147059-72-1.

What is the ChEBI ID of trovafloxacin?

The ChEBI ID of trovafloxacin is CHEMBL428.

What is the UNII of trovafloxacin?

The UNII of trovafloxacin is 9F388J00UK.

What is the XLogP3 value of trovafloxacin?

The XLogP3 value of trovafloxacin is 0.3.

Why was trovafloxacin withdrawn from the market?

Trovafloxacin was withdrawn from the market due to the risk of liver failure.