trans-Diamminedichloropalladium(II)

• CAS: 13782-33-7
• Catalog Number: ACM13782337-2
• Category: Main Products
• Molecular Weight: 211.39
• Molecular Formula: Pd(NH₃)2Cl2
• Synonyms: Palladium(II) diammine chloride
• Appearance: Yellow powder

Case Study

Trans-Diamminedichloropalladium(II) as an Internal Standard for the Determination of Cisplatin

Sudha T, et al. Nanomedicine, 2017, 12(3), 195-205.

This work reports the delivery efficiency of nano-diamino-tetrac (NDAT) for cisplatin to drug-sensitive bladder cancer xenografts. Specifically, NDAT-cisplatin was administered to xenograft nude mice, and tumor size response and drug content were measured. The results showed that NDAT significantly enhanced the delivery of cisplatin to bladder cancer xenografts and improved drug efficacy.
The experimental procedures involved the determination of cisplatin content in tumors by LC-MS/MS. Cisplatin stock solution and internal standard solution were prepared, as well as tissue samples from treated mice. The internal standard for cisplatin was trans-diamminedichloropalladium(II).
Stock solutions of cisplatin and the internal standard trans-diamminedichloropalladium(II) (TDPD) were created by dissolving them in a mixture of methanol and dimethyl sulfoxide (1:1, v/v), resulting in a concentration of 1 mg/mL. To establish a calibration curve, working solutions of cisplatin were formulated using methanol and water (1:1, v/v) at varying concentrations of 0.24, 0.49, 0.98, 1.95, 3.91, 7.81, 15.63, 31.25, 62.5, 125, 250, and 500 ng/mL. The internal standard solution was prepared by diluting the TDPD stock solution with the methanol/water mixture (1:1, v/v) to achieve a concentration of 250 ng/mL.

Custom Q&A

What is the molecular formula of trans-Diamminedichloropalladium(II)?

The molecular formula of trans-Diamminedichloropalladium(II) is Cl2H6N2Pd.

What are the synonyms for trans-Diamminedichloropalladium(II)?

The synonyms for trans-Diamminedichloropalladium(II) are 13782-33-7, Diamminedichloropalladium, Diammine dichloropalladium, and azane;dichloropalladium.

What is the molecular weight of trans-Diamminedichloropalladium(II)?

The molecular weight of trans-Diamminedichloropalladium(II) is 211.38 g/mol.

What are the component compounds of trans-Diamminedichloropalladium(II)?

The component compounds of trans-Diamminedichloropalladium(II) are Ammonia (CID 222) and Palladium(II) chloride (CID 24290).

When was trans-Diamminedichloropalladium(II) created?

Trans-Diamminedichloropalladium(II) was created on August 8, 2005.

When was trans-Diamminedichloropalladium(II) last modified?

Trans-Diamminedichloropalladium(II) was last modified on October 21, 2023.

What is the IUPAC name of trans-Diamminedichloropalladium(II)?

The IUPAC name of trans-Diamminedichloropalladium(II) is azane;dichloropalladium.

What is the InChIKey of trans-Diamminedichloropalladium(II)?

The InChIKey of trans-Diamminedichloropalladium(II) is WIEZTXFTOIBIOC-UHFFFAOYSA-L.

What is the CAS number of trans-Diamminedichloropalladium(II)?

The CAS number of trans-Diamminedichloropalladium(II) is 13782-33-7.

What is the molecular weight of trans-Diamminedichloropalladium(II) according to PubChem?

The molecular weight of trans-Diamminedichloropalladium(II) is 211.38 g/mol according to PubChem.