1,1,1,2-Tetrafluoroethane

• CAS: 811-97-2
• Catalog Number: ACM811972
• Category: Main Products
• Molecular Weight: 102.03
• Molecular Formula: C₂H₂F₄
• Synonyms: 1,1,1,2-Tetrafluorethan;1,1,1,2-tetrafluoroethane(hfc-134a);1,2,2,2-Tetrafluoroethane;AK134a;CF3CH2F;EcoloAce134a;ethane,1,1,1,2-tetrafluoro-;Forane134a
• IUPAC Name: 1,1,1,2-tetrafluoroethane
• Canonical SMILES: C(C(F)(F)F)F
• InChI Key: LVGUZGTVOIAKKC-UHFFFAOYSA-N
• Boiling Point: -26.5°C(lit.)
• Melting Point: -101°C
• Density: 1.21
• Appearance: colourless compressed gas
• Application: 1,1,1,2-Tetrafluoroethane, commonly known as a refrigerant in fridges, refrigerators, and automotive air conditioning systems, also serves as an aerosol propellant in medicine and cosmetics. Additionally, it is utilized as an animal-used antibiotic known for its stable quality and high antibacterial activity against various diseases in livestock and poultry, including E. coli disease, cholera, dysentery, and chronic respiratory infections.
• EC Number: 212-377-0
• Hazard Statements: Xi
• Safety Description: 23-38
• Supplemental Hazard Statements: H280
• Symbol: GHS04
• UN Number: 3159

Case Study

1,1,1,2-Tetrafluoroethane Research as a New Solvent

Corr, Stuart. Journal of Fluorine Chemistry 118.1-2 (2002): 55-67.

There is growing interest in the use of liquid 1,1,1,2-tetrafluoroethane (R-134a) as a solvent in both industrial and research activities. The solubility characteristics of R-134a are studied and its application in natural product extraction is described, where the solubility characteristics and convenient physical properties combine to make it a useful and viable alternative to traditional organic solvents and, in some cases, supercritical carbon dioxide (scCO ). R-134a can be considered as an aprotic, nonflammable, halogenated fluid that is stable to both acid and base aqueous solutions. R134a is not a volatile organic compound (VOC) and has no ozone depletion potential. R-134a is currently being investigated as a new solvent for the production of natural extracts in the flavor, fragrance, and nutrition sectors. R-134a is of high purity and cGMP compliant, is useful as a medical propellant, and is widely accepted as a solvent for food applications.
The R-134a extract is obtained by Soxhlet extraction of the biomass in a stainless steel pressure vessel for about 3 hours. The natural product is prepared and weighed into a cellulose thimble. The cellulose thimble containing the natural product is then placed in the Soxhlet extractor and a pre-weighed receiving flask is mounted in the appropriate position on the extractor. The glassware is placed in an autoclave equipped with a suitable condenser and heating coil, sealed and evacuated. The required amount of solvent is then transferred to the evacuated autoclave through a ball valve and resealed. The transfer of solvent to the autoclave raises the pressure in the autoclave and the solvent condenses into the glassware. The condenser and heating coil temperatures are then set at about 0 and 40 ± 8 °C, respectively, and the extraction is allowed to proceed for the desired period of time, typically 3-4 hours. After the extraction is complete, the solvent is recovered by opening the ball valve and condensing the solvent to cool. The autoclave is then opened and the glassware removed. The receiving flask is removed and reweighed to determine the yield. The extract samples were then analyzed by GC/MS using capillary columns (320 mm 25 m each) connected in series. The combination of columns provided good peak separation.

Hydrate equilibrium data of 1,1,1,2-tetrafluoroethane

Liang, Deqing, et al. Fluid Phase Equilibria 187 (2001): 61-70.

The liquid-water-hydrate-vapor (L-H-V) and ice-hydrate-vapor (I-H-V) three-phase equilibrium data of 1,1,1,2-tetrafluoroethane (HFC-134a) and 1,1-dichloroethane were determined and reported in this paper. The data were obtained in a sapphire cell with a magnetic stirrer and a data acquisition system over a range of temperatures (265.31-283.13, 268.41-281.49, and 264.72-288.15 K, respectively) and pressures (6-440, 6.2-40.2, and 49.5-443.7 kPa, respectively).
For the L-H-V three-phase experiments, the temperature was then increased stepwise, and at least 4 hours were required at each temperature to reach equilibrium. The temperature and pressure were continuously recorded, and the equilibrium data were plotted on a scatter plot. The point where the slope of the P-T curve changes sharply is considered to be the hydrate dissociation point. This is also confirmed by visual observation. For the I-H-V three-phase test, after the gas hydrate is formed, the temperature is then cooled to the desired temperature. After the gas hydrate is formed at the temperature, when the temperature and pressure in the tank are constant within 12 hours, the temperature and pressure are taken as equilibrium data. The estimated accuracy of the temperature and pressure measurements in the above experiments is ±0.05 K and ±1%, respectively. HCFC-141b and HFC-134a can form type II hydrates and fill the large cavities in type II hydrates, while HFC-152a can form type II hydrates or type I hydrates from its molecular size.

Custom Q&A

What is the molecular formula of 1,1,1,2-tetrafluoroethane?

The molecular formula of 1,1,1,2-tetrafluoroethane is C2H2F4.

What is another name for 1,1,1,2-tetrafluoroethane?

Another name for 1,1,1,2-tetrafluoroethane is Norflurane.

What is the CAS number of 1,1,1,2-tetrafluoroethane?

The CAS number of 1,1,1,2-tetrafluoroethane is 811-97-2.

What is the molecular weight of 1,1,1,2-tetrafluoroethane?

The molecular weight of 1,1,1,2-tetrafluoroethane is 102.03 g/mol.

Is 1,1,1,2-tetrafluoroethane a colorless gas?

Yes, 1,1,1,2-tetrafluoroethane appears as a colorless gas.

Can inhalation of 1,1,1,2-tetrafluoroethane at high concentrations be harmful?

Yes, inhalation of 1,1,1,2-tetrafluoroethane at high concentrations is harmful and may cause heart irregularities, unconsciousness, or death without warning.

What is the flash point of 1,1,1,2-tetrafluoroethane?

The flash point of 1,1,1,2-tetrafluoroethane is 351 °F.

Can liquid contact of 1,1,1,2-tetrafluoroethane cause frostbite?

Yes, liquid contact of 1,1,1,2-tetrafluoroethane can cause frostbite.

Can the vapors of 1,1,1,2-tetrafluoroethane replace the available oxygen?

Yes, the vapors of 1,1,1,2-tetrafluoroethane can replace the available oxygen.

What is the IUPAC name of 1,1,1,2-tetrafluoroethane?

The IUPAC name of 1,1,1,2-tetrafluoroethane is 1,1,1,2-tetrafluoroethane.