tert-Butyldimethylsilyl chloride

• CAS: 18162-48-6
• Catalog Number: ACM18162486-8
• Category: Silylation Reagents
• Molecular Weight: 150.72
• Molecular Formula: C6H15ClSi
• Synonyms: tert-Butyl(chloro)dimethylsilane, tert-Butyldimethylchlorosilane, TBDMSCl
• Boiling Point: 125 °C (lit.)
• Melting Point: 86-89 °C (lit.)
• Flash Point: 22 °C
• Density: 0.81 g/mL
• Appearance: White solid
• Application: Tert-Butyldimethylsilyl chloride is a versatile organosilicon compound that serves as a protective reagent for alcohols, amines, amides, and carboxylic acids. It is commonly used in organic synthesis to protect hydroxyl groups, particularly in the synthesis of prostaglandins and original drugs like hypolipaemics. Additionally, tert-Butyldimethylsilyl chloride plays a crucial role in the preparation of isoxazolines N-oxides from alpha-bromonitroalkanes and as an anion trapping reagent for lithio compounds and tin anions. Its diverse applications make it an essential tool in the field of organic chemistry.
• Storage: Store in dry, cool and well-ventilated place. Store at 5 °C place
• EC Number: 242-042-4
• Hazard Statements: H228; H314
• Packaging: 20 kg/ plastic drum, 25 kg/plastic drum, 200 L plastic drum, IBC drum
• Physical State: Solid
• Precautionary Statements: P210; P240; P241; P260; P264; P280; P301+P330+P331; P303+P361+P353; P304+P340; P305+P351+P338; P310; P321; P363; P370+P378; P405; P501
• Signal Word: Danger

Custom Reviews

2024-8-2

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Protective Agent for Hydroxyl Groups in Drug Synthesis
I recently used tert-Butyldimethylsilyl chloride from Alfa Chemistry in my research and found it to be a versatile protecting reagent for hydroxyl groups in drug synthesis. The sterically hindered organosilicon compound was easy to use and provided excellent protection for alcohols, amines, and amides. In my experiments, I was able to efficiently synthesize original drugs and create isoxazolines N-oxides with high yields. Overall, tert-Butyldimethylsilyl chloride proved to be a crucial component in my research and I highly recommend it for any scientist working in drug synthesis.