N,O-Bis(trimethylsilyl)trifluoroacetamide

• CAS: 25561-30-2
• Catalog Number: ACM25561302-1
• Category: Silylation Reagents
• Molecular Weight: 257.40
• Molecular Formula: C8H18F3NOSi2
• Synonyms: BSTFA
• Boiling Point: 45-50 °C/14 mmHg (lit.)
• Flash Point: 34 °C
• Density: 0.969 g/mL at 25 °C (lit.)
• Application: NO-Bis(Trimethylsilyl)Trifluoroacetamide is a versatile chemical reagent primarily used for the synthesis of pharmaceutical intermediates and the preparation of pyrimidinone ribosides and analogs that exhibit anti-tumor properties Its applications are diverse serving as a silylation reagent that facilitates the derivatization of a wide range of functional groups under mild conditions making it particularly useful in gas chromatography (GC) and mass spectrometry (MS) Its effectiveness has been demonstrated in metabolomics analysis such as measuring psychoactive amines in plants and acrylamide in food products NO-Bis(Trimethylsilyl)Trifluoroacetamide is used for analytical purposes or as a chemical reagent in creating more complex molecules displaying superior stability and yield compared to similar reagents in certain studies It finds utility in the derivatization of compounds like carboxylic acids phenols steroids and amines enhancing its role in scientific research and laboratory analysis
• Storage: Inert atmosphere,2-8 °C
• MDL Number: MFCD00008269
• Packaging: 10 g; 100 g
• Physical State: Liquid
• Precautionary Statements: P210-P280-P370+P378-P303+P361+P353-P304+P340+P310-P305+P351+P338+P310
• Signal Word: Danger

Synthetic Use

Upstream Synthesis Route 1

• 75-77-4
• 354-38-1

• 25561-30-2

Reference: [1]Chemische Berichte,1970,vol. 103,p. 553 - 560
[2]Tetrahedron Letters,1986,vol. 27,p. 347 - 348

Downstream Synthesis Route 1

• 79-14-1
• 25561-30-2

• 354-38-1
• 33581-77-0
• 55982-15-5

Reference: [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

Downstream Synthesis Route 2

• 849585-22-4
• 25561-30-2

• 354-38-1
• 17596-96-2
• 55982-15-5

Reference: [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

Downstream Synthesis Route 3

• 25561-30-2
• 66-22-8

• 10457-14-4

Reference: [1] Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 954 - 958
[2] Journal of Medicinal Chemistry, 1992, vol. 35, # 12, p. 2195 - 2201

Downstream Synthesis Route 4

• 1852-17-1
• 25561-30-2

• 18132-77-9

Reference: [1]Journal of Medicinal Chemistry,1981,vol. 24,p. 662 - 666

Downstream Synthesis Route 5

• 1820-81-1
• 25561-30-2

• 58990-53-7

Reference: [1]Journal of Medicinal Chemistry,1992,vol. 35,p. 2195 - 2201

* For details of the synthesis route, please refer to the original source to ensure accuracy.