Sulfadimethoxine

• CAS: 122-11-2
• Catalog Number: ACM122112-1
• Category: Main Products
• Molecular Weight: 310.33
• Molecular Formula: C12H14N4O4S
• Synonyms: Sulphadimethoxine
• IUPAC Name: 4-amino-N-(2,6-dimethoxypyrimidin-4-yl)benzenesulfonamide
• Canonical SMILES: COC1=NC(=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N)OC
• InChI Key: ZZORFUFYDOWNEF-UHFFFAOYSA-N
• Boiling Point: 548.5ºC at 760 mmHg
• Melting Point: 200ºC
• Flash Point: 285.5ºC
• Density: 1.441 g/cm³
• Appearance: Off-white powder
• EC Number: 204-523-7
• Exact Mass: 310.07400
• Hazard Statements: Xi: Irritant
• Packing Group: III
• Safety Description: 26-36/37-24/25-23
• Stability: Stable at normal temperatures and pressures.
• WGK Germany: 3

Case Study

Study on the Adsorption of Sulfadimethoxine and Sulfaguanidine in Soil

Bialk-Bielińska, Anna, et al. Chemosphere, 2012, 86(10), 1059-1065.

Sulfonamides (SA) are widely used in veterinary medicine, such as sulfadimethoxine (SDM) and sulfaguanidine (SGD), and they are used in agriculture for disease prevention and treatment of livestock diseases. However, since soil is most susceptible to contamination by these substances, their dispersion in soil needs to be evaluated. This work investigated the adsorption mechanism of sulfonamides (SDM and SGD) on three natural soils.
Adsorption behavior of SDM and SGD in soil
· The study found that sulfadimethoxine (SDM) and sulfaguanidine (SGD) sorb to soil to a lesser extent compared to other antibiotics, with adsorption coefficients influenced by soil properties such as pH, organic carbon (OC), cation exchange capacity (CEC), and ionic strength.
· Higher OC content increased adsorption, while higher pH and ionic strength decreased it.
· Sulfonamides can be immobilized by high organic matter and low pH, reducing the risk of contamination. However, cationic species may sorb more in acidic environments.
· The mobility and bioavailability of sulfonamides suggest they are highly mobile and easily transported, posing a risk of surface and groundwater contamination. Research on bioaccumulation is limited, but their strong phytotoxic properties raise environmental concerns.
· Multiple linear regression identified pH and clay fraction content as major factors affecting sorption of sulfonamides in soil.

Custom Q&A

What is the molecular formula of sulfadimethoxine?

The molecular formula of sulfadimethoxine is C12H14N4O4S.

What are some synonyms for sulfadimethoxine?

Some synonyms for sulfadimethoxine are Sulphadimethoxine, 122-11-2, and Sulfadimethoxydiazine.

What is the molecular weight of sulfadimethoxine?

The molecular weight of sulfadimethoxine is 310.33 g/mol.

What is the role of sulfadimethoxine?

Sulfadimethoxine has the role of an antiinfective agent, an antimicrobial agent, a xenobiotic, an environmental contaminant, and a drug allergen.

What is the function of sulfadimethoxine as an antibiotic?

Sulfadimethoxine inhibits bacterial synthesis of folic acid (pteroylglutamic acid) from para-aminobenzoic acid.

In which country is sulfadimethoxine approved for use in humans?

Sulfadimethoxine is approved for use in humans in Russia.

How long has sulfadimethoxine been successfully used in Russia?

Sulfadimethoxine has been successfully used in Russia for more than 35 years.

Is sulfadimethoxine widely available as an over-the-counter drug in Russia?

Yes, sulfadimethoxine is widely available in Russia as an over-the-counter drug manufactured by a number of Russian pharmaceutical companies.

Has sulfadimethoxine been withdrawn or removed from the market in the US?

Yes, sulfadimethoxine is one of the products that have been withdrawn or removed from the market in the US after being found to be unsafe or not effective.

Where is sulfadimethoxine found as a natural product?

Sulfadimethoxine is found as a natural product in Brassica napus in LOTUS, the natural products occurrence database.