CAS
50886-61-8 Purity
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50886-61-8 Purity
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Shikonin
CAS
517-89-5
Catalog Number
ACM517895
Category
Inhibitors
Molecular Weight
288.30
Molecular Formula
C16H16O5
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Specification
Description
Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation.
Synonyms
C.I. 75535
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