SC-10914

• CAS: 76985-08-5
• Catalog Number: ACM76985085
• Category: Inhibitors
• Molecular Weight: 241.29
• Molecular Formula: C15H15NO2
• Description: SC10914 is a highly potent PARP inhibitor (PARP1 IC50 = 7.87 nM) with potent anti-proliferative activity against human BRCA deficient tumor cells (MDA-MB-436, BRCA1 deficient, IC50 = 4.03 nM, Capan-1 BRCA2 deficient, IC50 = 11.66 nM) and PTEN deficient tumor cells (HGC-27,PTEN deficient, IC50 = 0.35 μM). SC10914 showed potent anti-tumor activity in BRCA1/2 mutant tumor models and better pharmacokinetics profile has the potential to be selected as the clinical candidate for the treatment of treatment of BRCA1/2 deficient cancers.
• Synonyms: SC-10914; SC 10914; SC10914
• IUPAC Name: 2-Amino-3-(4-biphenylyl)propanoic acid
• Canonical SMILES: O=C(O)C(N)CC1=CC=C(C2=CC=CC=C2)C=C1
• InChI: InChI=1S/C15H15NO2/c16-14(15(17)18)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9,14H,10,16H2,(H,17,18)
• InChI Key: JCZLABDVDPYLRZ-UHFFFAOYSA-N
• Solubility: To be determined
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Alternative CAS: 76985-08-5 (free base); 63024-23-7 (HCl); 155760-02-4 (S-isomer); 170080-13-4 (R-isomer); 63087-78-5 (S-isomer HCl); 2159063-18-8 (R-isomer HCl)
• Biological Target: SC10914 is a highly potent PARP inhibitor (PARP1 IC50 = 7.87 nM) with potent anti-proliferative activity against human BRCA deficient tumor cells (MDA-MB-436, BRCA1 deficient, IC50 = 4.03 nM, Capan-1 BRCA2 deficient, IC50 = 11.66 nM) and PTEN deficient tumor cells (HGC-27,PTEN deficient, IC50 = 0.35 μM).
• Drug Formulation: To be determined
• Elemental Analysis: C, 74.67; H, 6.27; N, 5.81; O, 13.26
• Exact Mass: 241.1103
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: TBD
• In Vivo Activity: TBD
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).