JX-06

• CAS: 729-46-4
• Catalog Number: ACM729464
• Category: Inhibitors
• Molecular Weight: 324.49
• Molecular Formula: C10H16N2O2S4
• Description: JX-06 is a potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor (IC50 values are 28, 49 and 313 nM for PDK2, PDK1 and PDK3, respectively). JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification. JX06, as a selective covalent inhibitor of PDK1 in cells, forms a disulfide bond with the thiol group of a conserved cysteine residue (C240) based on recognition of a hydrophobic pocket adjacent to the ATP pocket of the PDK1 enzyme.
• Synonyms: JX-06; JX 06; JX06
• IUPAC Name: Bis(morpholinothiocarbonyl) disulfide
• Canonical SMILES: S=C(SSC(N1CCOCC1)=S)N2CCOCC2
• InChI: InChI=1S/C10H16N2O2S4/c15-9(11-1-5-13-6-2-11)17-18-10(16)12-3-7-14-8-4-12/h1-8H2
• InChI Key: KKVYOWPPMNSLCP-UHFFFAOYSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 37.02; H, 4.97; N, 8.63; O, 9.86; S, 39.52
• Exact Mass: 324.0095
• HS Tariff Code: 2934.99.9001
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).