Puromycin Aminonucleoside

• CAS: 58-60-6
• Catalog Number: ACM58606
• Category: Inhibitors
• Molecular Weight: 294.32
• Molecular Formula: C12H18N6O3
• Description: Puromycin Aminonucleoside, also known as PAN, NSC3056, is useful in the study of human glomerular disease, and glomerular function and morphology. PAN is used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability.PAN treatment increased oxidative stress level of podocytes significantly with the induction of Nox4. Puromycin aminonucleoside increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.
• Synonyms: Puromycin Aminonucleoside; ARDMA; NSC 3056; SAN; Stylomycin aminonucleoside
• IUPAC Name: (2R,3R,4S,5S)-4-amino-2-(6-(dimethylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-ol
• Canonical SMILES: O[C@H]([C@@H]1N)[C@@H](O[C@@H]1CO)N2C(N=CN=C3N(C)C)=C3N=C2
• InChI: InChI=1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3/t6-,7-,9-,12-/m1/s1
• InChI Key: RYSMHWILUNYBFW-GRIPGOBMSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 48.97; H, 6.16; N, 28.56; O, 16.31
• Exact Mass: 294.144
• HS Tariff Code: 2934.99.9001
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).