Methoxypolyethylene glycols

• CAS: 9004-74-4
• Catalog Number: ACM9004744-19
• Category: Main Products
• Molecular Weight: 120.15
• Molecular Formula: C5H12O3
• Synonyms: Polyethylene glycol monomethyl ether
• Melting Point: 60-64 °C
• Appearance: White paste liquid
• Physical State: Semisolid
• Storage Conditions: -20 °C

Case Study

Drug Release Study Of Methoxypolyethylene Glycol Copolymeric Micelles Containing Indomethacin

Kim, So Yeon, et al. Journal of Controlled Release 51.1 (1998): 13-22.

Amphiphilic diblock copolymers consisting of methoxypolyethylene glycol (MePEG) and '-caprolactone ('-CL) were prepared by MePEG-initiated '-CL polymerization. MePEG/'-CL block copolymeric micelles containing indomethacin (IMC) were prepared by dialysis and evaluated as novel drug carriers. The size of the formed micelles was less than 200 nm, and the micelle size distribution showed a narrow and monodisperse unimodal pattern. In addition, the micelles formed by the dialysis method exhibited a spherical structure. For those prepared using copolymers with a molecular weight of about 12 000 and a polymer/IMC weight ratio of 1/1, the content of indomethacin in the nanospheres was about 42.2%. The release rate of indomethacin from the nanospheres was slow, so that the release was sustained for more than 15 days. The release rate decreased with the increase of the copolymer molecular weight and the amount of encapsulated drug. These results indicate that the drug-loaded nanospheres can be used as novel drug carriers in hydrophobic drug injection delivery systems. ,
MePEG/'-CL diblock copolymers were prepared by polymerization of '-caprolactone to remove unbound IMC and aggregated IMCMePEG, the obtained micellar solution was sonicated, centrifuged and tested with various copolymer compositions in Table 1, and then lyophilized. Subsequently, the nanospheres were edited. The "MEP series" was obtained by freeze-drying micelles with a fixed molecular weight of 5000 in the MePEG chain and the PCL part was broken from M/I535 to 150 by adding ethanol and THF. MePEG/'-CL (1:1 v/v), the amount of IMC entrapped was the deblocked copolymer containing IMC. MePEG/'-CL block copolymer (100 mg) was dissolved in 10 mL of the '-caprolactone part of the nanospheres in 10 mL of selected organic solvents, which were determined according to the weight of the nanospheres and the amount of drug loaded such as dimethylformamide (DMF), tetrahydrofuran (THF), dimethylacetamide (DMA) and dichloromethane from the following equation.

Custom Q&A

What is the molecular formula of Methoxypolyethylene glycols?

The molecular formula of Methoxypolyethylene glycols is C25H52O13.

What is the exact mass of Methoxypolyethylene glycols?

The exact mass of Methoxypolyethylene glycols is 560.34079171.

What is the Canonical SMILES of Methoxypolyethylene glycols?

The Canonical SMILES of Methoxypolyethylene glycols is COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO.

How many hydrogen bond acceptor count does Methoxypolyethylene glycols have?

Methoxypolyethylene glycols has 13 hydrogen bond acceptor count.

What is the Computed Properties Rotatable Bond Count of Methoxypolyethylene glycols?

The Computed Properties Rotatable Bond Count of Methoxypolyethylene glycols is 35.

What are some Depositor-Supplied Synonyms for Methoxypolyethylene glycols?

Some Depositor-Supplied Synonyms for Methoxypolyethylene glycols are Dodecaethylene Glycol Monomethyl Ether, mPEG12-OH, and Methyl-PEG12-alcohol.

What is the InChIKey for Methoxypolyethylene glycols?

The InChIKey for Methoxypolyethylene glycols is PLQZJIIDLZRWBG-UHFFFAOYSA-N.

What is the IUPAC Name of Methoxypolyethylene glycols?

The IUPAC Name of Methoxypolyethylene glycols is 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol.

What is the average molecular weight (M.W.) of Methoxypolyethylene glycols?

The average molecular weight of Methoxypolyethylene glycols is 560.7g/mol.

What is the PubChem Compound ID for Methoxypolyethylene glycols?

The PubChem Compound ID for Methoxypolyethylene glycols is 14550548.