MCU-i4

• CAS: 371924-24-2
• Catalog Number: ACM371924242
• Category: Others
• Molecular Weight: 377.49
• Molecular Formula: C23H27N3O2
• Description: MCU-i4 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.
• Synonyms: MCU-i4; MCUi4; MCU i4
• IUPAC Name: Ethyl 4-((4-(diethylamino)phenyl)amino)-6-methylquinoline-3-carboxylate
• Canonical SMILES: O=C(C1=C(NC2=CC=C(N(CC)CC)C=C2)C3=CC(C)=CC=C3N=C1)OCC
• InChI: InChI=1S/C23H27N3O2/c1-5-26(6-2)18-11-9-17(10-12-18)25-22-19-14-16(4)8-13-21(19)24-15-20(22)23(27)28-7-3/h8-15H,5-7H2,1-4H3,(H,24,25)
• InChI Key: RIWXBJCWHVMATR-UHFFFAOYSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >3 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: MCU-i4 blocks the IP3-dependent mitochondrial Ca2+-uptake, maintaining the gatekeeping role of their target.
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 73.18; H, 7.21; N, 11.13; O, 8.48
• Exact Mass: 377.2103
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: For this purpose, this study measured mitochondrial Ca2+ uptake speed in cells permeabilized with digitonin and then perfused with 3 μM Ca2+ in the presence of the active molecules (Figure 2C). MCU-i4 and MCU-i11 decreased mitochondrial Ca2+ uptake speed. These results confirm that the selected compounds impinge directly on the MCU complex activity rather than on Ca2+ release from intracellular stores or on cytosolic [Ca2+].; Reference: Cell Rep. 2020 Feb 18;30(7):2321-2331.e6. https://pubmed.ncbi.nlm.nih.gov/32075766/
• In Vivo Activity: Both MCU-i4 and MCU-i11 inhibited mitochondrial Ca2+ uptake in myofibers (Figure 5C). Both compounds decreased myotube width (Figure 5D). These data prove the efficacy of MCU-i4 and MCU-i11 ex vivo and indicate that pharmacological modulation of mitochondrial Ca2+ uptake interferes with an essential biological process.; Reference: Cell Rep. 2020 Feb 18;30(7):2321-2331.e6. https://pubmed.ncbi.nlm.nih.gov/32075766/
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).