KY-226

• CAS: 1621673-53-7
• Catalog Number: ACM1621673537
• Category: Inhibitors
• Molecular Weight: 481.67
• Molecular Formula: C27H31NO3S2
• Description: KY-226 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that protects neurons from cerebral ischemic injury. KY-226 restores Akt (protein kinase B) phosphorylation and extracellular signal-regulated kinase (ERK) reduction in transient middle cerebral artery occlusion (tMCAO) damage. KY-226 protects BBB integrity by restoration of TJ proteins, an effect partly mediated by Akt/FoxO1 pathway activation.
• Synonyms: KY-226; KY 226; KY226
• IUPAC Name: 4-(biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide
• Canonical SMILES: O=C(NS(=O)(CCCCCC)=O)C1=CC=C(CSCC2=CC=C(C3=CC=CC=C3)C=C2)C=C1
• InChI: InChI=1S/C27H31NO3S2/c1-2-3-4-8-19-33(30,31)28-27(29)26-17-13-23(14-18-26)21-32-20-22-11-15-25(16-12-22)24-9-6-5-7-10-24/h5-7,9-18H,2-4,8,19-21H2,1H3,(H,28,29)
• InChI Key: MKXMABKUVSOEJF-UHFFFAOYSA-N
• Solubility: Soluble in DMSO
• Appearance: Fluffy white solid powder
• Shelf Life: >3 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: KY-226 is a potent, selective, orally active and allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 0.25 μM.
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 67.33; H, 6.49; N, 2.91; O, 9.96; S, 13.31
• Exact Mass: 481.1745
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: KY-226 inhibited PTP1B activity at 0.1-10 μM, and the IC50 value was 0.28 ± 0.01 μM (mean ± S.E.M, n = 6).; Reference: J Pharmacol Sci. 2018 May;137(1):38-46. https://pubmed.ncbi.nlm.nih.gov/29731242/
• In Vivo Activity: KY-226 at 10 and 30 mg/kg/day did not exhibit toxicity, and significantly reduced non-fasting plasma glucose and TG levels without increasing body weight gain in db/db mice (Fig. 4A). HFD-feeding markedly increased body weight gain, fat volume gain, and reduced food consumption, possibly due to the high calorie diet. KY-226 did not exhibit toxicity, significantly reduced body weight gain at 30 and 60 mg/kg/day, and reduced total food consumption and visceral fat volume gain at 60 mg/kg/day (Fig. 7A-D).; Reference: J Pharmacol Sci. 2018 May;137(1):38-46. https://pubmed.ncbi.nlm.nih.gov/29731242/
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).