Tenalisib

• CAS: 1639417-53-0
• Catalog Number: ACM1639417530
• Category: Inhibitors
• Molecular Weight: 415.43
• Molecular Formula: C23H18FN5O2
• Description: Tenalisib, also known as RP6530, is a potent and selective dual PI3Kδ/γ inhibitor that inhibited growth of B-cell lymphoma cell lines with a concomitant reduction in the downstream biomarker, pAKT. Additionally, the compound showed cytotoxicity in a panel of lymphoma primary cells. Findings provide a rationale for future clinical trials in B-cell malignancies.
• Synonyms: RP6530; RP-6530; RP 6530; Tenalisib
• IUPAC Name: (S)-2-(1-((7H-purin-6-yl)amino)propyl)-3-(3-fluorophenyl)-4H-chromen-4-one
• Canonical SMILES: O=C1C(C2=CC=CC(F)=C2)=C([C@@H](NC3=C4NC=NC4=NC=N3)CC)OC5=C1C=CC=C5
• InChI: InChI=1S/C23H18FN5O2/c1-2-16(29-23-19-22(26-11-25-19)27-12-28-23)21-18(13-6-5-7-14(24)10-13)20(30)15-8-3-4-9-17(15)31-21/h3-12,16H,2H2,1H3,(H2,25,26,27,28,29)/t16-/m0/s1
• InChI Key: HDXDQPRPFRKGKZ-INIZCTEOSA-N
• Solubility: Soluble in DMSO, not in water
• Appearance: White solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Alternative CAS: 1639417-53-0; 1693773-94-2
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 66.50; H, 4.37; F, 4.57; N, 16.86; O, 7.70
• Exact Mass: 415.1445
• HS Tariff Code: 2934.99.9001
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).