Itraconazole

• CAS: 84625-61-6
• Catalog Number: ACM84625616
• Category: Inhibitors
• Molecular Weight: 705.63
• Molecular Formula: C35H38Cl2N8O4
• Description: Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.
• Synonyms: 3H-1,2,4-Triazol-3-one, 4-(4-(4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihydro-2-(1-methylpropyl)-;(+-)-1-sec-Butyl-4-(p-(4-(p-(((2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-delta(sup 2)-1,2,4-triazolin-5-one
• Canonical SMILES: ClC1=C(C=CC(Cl)=C1)[C@@]2(O[C@@H](COC3=CC=C(N4CCN(C5=CC=C(N(C=NN6C(C)CC)C6=O)C=C5)CC4)C=C3)CO2)CN7C=NC=N7
• Melting Point: 166°C
• Flash Point: 467.9°C
• Density: 1.4 g/cm³
• Solubility: water, 0.0004719 mg/L @ 25 °C (est)
• Appearance: Off-white crystalline solid
• Storage: 4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light).
• Active Content: 95%
• Assay: 0.99
• EC Number: 283-347-2
• MDL Number: MFCD00870168
• Packaging: 1 kg
• Physical State: Solid
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Stability: Stable. Incompatible with strong oxidizing agents.
• Storage Conditions: 2-8°C