Irinotecan hydrochloride

• CAS: 100286-90-6
• Catalog Number: ACM100286906
• Category: Inhibitors
• Molecular Weight: 623.1
• Description: Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer.
• Synonyms: Camptothecin II
• InChI: InChI=1S/C33H38N4O6.ClH/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H/t33-;/m0./s1
• InChI Key: GURKHSYORGJETM-WAQYZQTGSA-N
• Melting Point: 250-256 °C
• Complexity: 1200
• Covalently-Bonded Unit Count: 2
• Defined Atom Stereocenter Count: 1
• Exact Mass: 622.2558127
• Heavy Atom Count: 44
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 2
• Isomeric SMILES: CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.Cl
• Monoisotopic Mass: 622.2558127
• Physical State: Powder
• Rotatable Bond Count: 5
• Topological Polar Surface Area: 113 Ų

Custom Q&A

What is the chemical formula of Irinotecan hydrochloride?

The chemical formula of Irinotecan hydrochloride is C33H39ClN4O6.

What is the storage temperature recommended for Irinotecan hydrochloride?

The recommended storage temperature for Irinotecan hydrochloride is 2-8°C.

How is Irinotecan hydrochloride primarily eliminated from the body?

Irinotecan hydrochloride is primarily eliminated through bile, with a minor amount of renal elimination.

What is the active metabolite of Irinotecan hydrochloride, and how does it compare to the parent drug?

The active metabolite of Irinotecan hydrochloride is SN-38, which is 1000-fold more potent than the parent drug.

What are the two dose-limiting toxicities of Irinotecan hydrochloride?

The two dose-limiting toxicities of Irinotecan hydrochloride are myelosuppression and diarrhea.

What are the main side effects associated with Irinotecan hydrochloride treatment?

The main side effects associated with Irinotecan hydrochloride treatment are leukopenia, diarrhea, nausea, vomiting, and alopecia.

What is the therapeutic function of Irinotecan hydrochloride?

The therapeutic function of Irinotecan hydrochloride is antineoplastic, meaning it is used for the treatment of cancer.

How is Irinotecan hydrochloride bioactivated in the body?

Irinotecan hydrochloride is slowly bioactivated in the liver through hydrolysis of the C10-carbamate ester by a specific enzyme.

What is the recommended treatment for the diarrhea induced by Irinotecan hydrochloride?

The recommended treatment for the diarrhea induced by Irinotecan hydrochloride is vigorous loperamide therapy.

In what types of cancers is Irinotecan hydrochloride used in combination therapy?

Irinotecan hydrochloride is used in combination therapy for gastrointestinal, breast, skin, colorectal, pancreatic cancers, mesothelioma, and non-Hodgkin's lymphoma.