Bullatine A

• CAS: 1354-84-3
• Catalog Number: ACM1354843
• Category: Inhibitors
• Molecular Weight: 343.5
• Description: Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A is a potent P2X7 antagonist, inhibits ATP-induced cell death/apoptosis and P2X receptor-mediated inflammatory responses. Bullatine A attenuates pain hypersensitivity, regardless of the pain models employed.
• InChI: InChI=1S/C22H33NO2/c1-4-23-11-20(3)7-5-8-22-15(20)10-14(18(22)23)21-9-6-13(12(2)19(21)25)16(24)17(21)22/h13-19,24-25H,2,4-11H2,1,3H3/t13,14,15-,16+,17+,18,19-,20+,21,22/m1/s1
• InChI Key: OVXLNQAYPUEDSI-LVIQKLEBSA-N
• Complexity: 662
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 5
• Exact Mass: 343.251129295
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• Isomeric SMILES: CCN1C[C@@]2(CCCC34[C@@H]2CC(C31)C56[C@@H]4[C@H](C(CC5)C(=C)[C@H]6O)O)C
• Monoisotopic Mass: 343.251129295
• Physical State: Powder
• Rotatable Bond Count: 1
• Topological Polar Surface Area: 43.7 Ų