Honokiol

• CAS: 35354-74-6
• Catalog Number: ACM35354746
• Category: Inhibitors
• Molecular Weight: 266.33
• Molecular Formula: C18H18O2
• Description: Honokiol is a bioactive, biphenolic phytochemical that possesses potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting a variety of signaling molecules. It inhibits the activation of Akt. Honokiol can readily cross the blood brain barrier.
• Synonyms: 3',5-Diallyl-2,4'-biphenyldiol
• IUPAC Name: 2-(4-Hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
• Canonical SMILES: C=CCC1=CC(=C(C=C1)O)C2=CC(=C(C=C2)O)CC=C
• InChI: InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2
• InChI Key: FVYXIJYOAGAUQK-UHFFFAOYSA-N
• Boiling Point: 400.1±40.0 °C
• Melting Point: 86 °C
• Flash Point: 184°C
• Density: 1.107±0.06 g/ml
• Appearance: White powder
• Active Content: 95%
• Assay: 0.999
• Packaging: 1 ton
• Physical State: Solid
• pKa: 9.89±0.48
• Refractive Index: 1.6
• Stability: Stable at normal temperatures and pressures.
• Storage Conditions: 2-8°C

Synthetic Use

Upstream Synthesis Route 1

• 29415-97-2

• 35354-74-6

Reference: [1]Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,p. 2621 - 2625

Downstream Synthesis Route 1

• 35354-74-6

• 35406-31-6

Reference: [1]Bioorganic and Medicinal Chemistry,2019,vol. 27,p. 3729 - 3734
[2]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 163 - 166
[3]Chemical and pharmaceutical bulletin,1972,vol. 20,p. 212 - 213
[4]Bioorganic and Medicinal Chemistry,2015,vol. 23,p. 6757 - 6762
[5]Molecules,2020,vol. 25

Downstream Synthesis Route 2

• 108-31-6
• 35354-74-6

• 1048647-35-3

Reference: [1]Patent: WO2008/99994,2008,A1 .Location in patent: Page/Page column 23-24

* For details of the synthesis route, please refer to the original source to ensure accuracy.