Homoharringtonine

• CAS: 26833-87-4
• Catalog Number: ACM26833874-3
• Category: Main Products
• Molecular Weight: 545.62
• Molecular Formula: C29H39NO9
• Synonyms: Omacetaxine
• IUPAC Name: 1-O-[(2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-yl] 4-O-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
• Canonical SMILES: CC(C)(CCC[C@@](CC(=O)OC)(C(=O)O[C@H]1[C@H]2C3=CC4=C(C=C3CCN5[C@@]2(CCC5)C=C1OC)OCO4)O)O
• InChI: InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1
• InChI Key: HYFHYPWGAURHIV-JFIAXGOJSA-N
• Boiling Point: 619.03 °C
• Melting Point: 144-146 °C
• Flash Point: 385.1ºC
• Density: 1.24 g/ml
• Appearance: White powder
• Exact Mass: 545.26200
• Hazard Statements: T+: Very toxic;Xi: Irritant
• Packing Group: II
• pKa: 11.60±0.29
• Safety Description: 36/37/39-45-27-26
• WGK Germany: 3

Case Study

Homoharringtonine (HHT) as a Synergistic Agent in the Treatment of Early T Cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL)

Suo S, et al. Med, 2024, 5(12), 1510-1524.

Homoharringtonine (HHT) has demonstrated significant potential in the treatment of ETP-ALL, a subtype of T-ALL with a poor prognosis. In combination with the BCL-2 inhibitor venetoclax (VEN), HHT was shown to induce strong synergistic effects both in vitro and in vivo, enhancing apoptosis in ETP-ALL cells. The mechanistic investigation revealed that this combination downregulated key anti-apoptotic proteins, such as MCL1, which play a pivotal role in promoting cell survival. The preclinical results were confirmed in clinical trials where six patients with either refractory/relapsed (R/R) or newly diagnosed ETP-ALL achieved complete remission (CR) after just one cycle of HHT/VEN-based treatment. Given its clinical approval and promising results in preclinical models, HHT is positioned as a critical component of a safe and effective regimen for treating ETP-ALL. The combination of HHT and VEN may offer a new therapeutic approach, enhancing the efficacy of treatments for this aggressive and challenging cancer subtype.

Custom Q&A

What is the chemical formula of Homoharringtonine?

The chemical formula of Homoharringtonine is C29H39NO9.

What are some synonyms of Homoharringtonine?

Some synonyms of Homoharringtonine include Omacetaxine mepesuccinate, Ceflatonin, Myelostat, Synribo, CGX-635, Omapro, and Homoharringtonin.

What is the molecular structure of Homoharringtonine?

The molecular structure of Homoharringtonine can be seen in the provided 2D and 3D images.

What is the chemical safety profile of Homoharringtonine?

The reference does not provide specific information about the chemical safety profile of Homoharringtonine.

What is the main source of Homoharringtonine?

Homoharringtonine is derived from the plant Cephalotaxus harringtonia.

What is the primary use of Homoharringtonine?

Homoharringtonine is used for the treatment of chronic illnesses.

Is Homoharringtonine a natural compound or a synthetic compound?

Homoharringtonine is a natural compound derived from Cephalotaxus harringtonia.

What is the common trade name of Homoharringtonine?

The common trade name of Homoharringtonine is Synribo.

What is the PubChem ID of Homoharringtonine?

The PubChem ID of Homoharringtonine is 285033.

What is the date of creation and modification of the reference?

The reference was created on March 26, 2005, and last modified on August 26, 2023.