Fmoc-Lys(Z)-OH

• CAS: 86060-82-4
• Catalog Number: ACM86060824
• Category: Amino Acids
• Molecular Weight: 502.56
• Description: Building block for introduction of lysine amino-acid residues by Fmoc SPPS. The side-chain protecting group is TFA-stable but can be removed by hydrogenation over Pd/C or with strong acids such as TFMSA.
• Synonyms: Fmoc-Lys(Z)-OH, N-α-Fmoc-N-ε-benzyloxycarbonyl-L-lysine
• InChI: 1S/C29H30N2O6/c32-27(33)26(16-8-9-17-30-28(34)36-18-20-10-2-1-3-11-20)31-29(35)37-19-25-23-14-6-4-12-21(23)22-13-5-7-15-24(22)25/h1-7,10-15,25-26H,8-9,16-19H2,(H,30,34)(H,31,35)(H,32,33)/t26-/m0/s1
• InChI Key: KRULQRVJXQQPQH-SANMLTNESA-N
• Melting Point: 105-115℃
• Application: Peptide synthesis.
• Assay: ≥95.0% (acidimetric); ≥98% (TLC); ≥98.0% (HPLC)
• Form: powder
• Functional Group: amine
• MDL Number: MFCD00065662
• Quality Level: 200
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Storage Temperature: 2-30℃

Synthetic Use

Upstream Synthesis Route 1

• 1155-64-2
• 28920-43-6

• 86060-82-4

Reference: [1] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 15, p. 5616 - 5625
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 19, p. 6456 - 6468
[3] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986, vol. 25, p. 1045 - 1049
[4] Journal of Organic Chemistry, 1989, vol. 54, # 23, p. 5551 - 5558

Upstream Synthesis Route 2

• 1155-64-2
• 88744-04-1

• 86060-82-4

Reference: [1] Synthesis, 1986, # 4, p. 303 - 305

Upstream Synthesis Route 3

• 1155-64-2
• 28920-43-6

• 86060-82-4

Reference: [1]Bioorganic and Medicinal Chemistry,2010,vol. 18,p. 5616 - 5625
[2]Journal of Medicinal Chemistry,2011,vol. 54,p. 6456 - 6468
[3]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1986,vol. 25,p. 1045 - 1049
[4]Journal of Organic Chemistry,1989,vol. 54,p. 5551 - 5558

Downstream Synthesis Route 1

• 6066-82-6
• 86060-82-4

• 116064-01-8

Reference: [1]Tetrahedron,1987,vol. 43,p. 5961 - 5972
[2]Bioorganic Chemistry,2018,vol. 81,p. 211 - 221

Downstream Synthesis Route 2

• 771-61-9
• 86060-82-4

• 86060-97-1

Reference: [1]Synthesis,1983,p. 325 - 327
[2]Synthesis,1986,p. 303 - 305

* For details of the synthesis route, please refer to the original source to ensure accuracy.