Fmoc-Arg(Pbf)-OH

• CAS: 154445-77-9
• Catalog Number: ACM154445779-1
• Category: Amino Acids
• Molecular Weight: 648.77
• Molecular Formula: C34H40N4O7S
• Description: High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities.; The standard derivative for the introduction of Arg in Fmoc SPPS. The Pbf side-chain protecting group is removed with TFA approximately 1-2 times faster than Pmc.In the preparation of peptides containing both Arg and Trp, it is recommended that this derivative is used in conjunction with Fmoc-Trp(Boc)-OH.
• Synonyms: Fmoc-Arg(Pbf)-OH, N-α-Fmoc-N G-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine
• IUPAC Name: (2S)-5-[[amino-[(2,2,4,6,7-pentamethyl-3H-1-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid
• Canonical SMILES: CC1=C(C(=C(C2=C1OC(C2)(C)C)C)S(=O)(=O)NC(=NCCC[C@@H](C(=O)O)NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35)N)C
• InChI: 1S/C34H40N4O7S/c1-19-20(2)30(21(3)26-17-34(4,5)45-29(19)26)46(42,43)38-32(35)36-16-10-15-28(31(39)40)37-33(41)44-18-27-24-13-8-6-11-22(24)23-12-7-9-14-25(23)27/h6-9,11-14,27-28H,10,15-18H2,1-5H3,(H,37,41)(H,39,40)(H3,35,36,38)/t28-/m0/s1
• InChI Key: HNICLNKVURBTKV-NDEPHWFRSA-N
• Melting Point: >65℃
• Density: 1.37±0.1 g/ml
• Appearance: White to off-white solid
• Application: Peptide synthesis.
• Assay: ≥98% (TLC); ≥99.0% (HPLC)
• Form: powder
• Functional Group: Fmoc
• Hazard Statements: Xi
• MDL Number: MFCD00235804
• pKa: 3.83±0.21
• Quality Level: 400
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Safety Description: 26-36
• Storage Temperature: -10 to -25℃
• Type: Unlabeled Standard Amino Acids, Arginine (Arg)