Fluorofenidone

• CAS: 848353-85-5
• Catalog Number: ACM848353855
• Category: Inhibitors
• Molecular Weight: 203.22
• Molecular Formula: C12H10FNO
• Description: Fluorofenidone is a NADPH-oxidase inhibitor. Fluorofenidone Inhibits UUO/IRI-Induced Renal Fibrosis by Reducing Mitochondrial Damage. Fluorofenidone protects liver against inflammation and fibrosis by blocking the activation of NF-κB pathway. Fluorofenidone attenuates paraquat‑induced pulmonary fibrosis by regulating the PI3K/Akt/mTOR signaling pathway and autophagy. Fluorofenidone inhibits apoptosis of renal tubular epithelial cells in rats with renal interstitial fibrosis.
• IUPAC Name: 1-(3-Fluorophenyl)-5-methylpyridin-2-one
• Canonical SMILES: O=C1C=CC(C)=CN1C2=CC=CC(F)=C2
• InChI: InChI=1S/C12H10FNO/c1-9-5-6-12(15)14(8-9)11-4-2-3-10(13)7-11/h2-8H,1H3
• InChI Key: JDZYVVUJIQYGRX-UHFFFAOYSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 70.93; H, 4.96; F, 9.35; N, 6.89; O, 7.87
• Exact Mass: 203.0746
• HS Tariff Code: 2934.99.9001
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).