Dexamethasone acetate

• CAS: 1177-87-3
• Catalog Number: ACM1177873
• Category: Inhibitors
• Molecular Weight: 434.5
• Molecular Formula: C₂₄H₃₁FO₆
• Description: Dexamethasone acetate (Dexamethasone 21-acetate) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
• Synonyms: DEXAMETHASONE 21-ACETATE; DexaMethasone 21-Acetate; 9α-Fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-Acetate; Dexamethasone Acetate
• IUPAC Name: Dexamethasone-17-acetate
• Canonical SMILES: C[C@@]1([C@@]2(O)C(COC(C)=O)=O)[C@](C[C@H]2C)([H])[C@@](CCC3=CC4=O)([H])[C@@](F)([C@]3(C=C4)C)[C@@H](O)C1
• Boiling Point: 579.4ºC at 760 mmHg
• Melting Point: 238-240ºC
• Flash Point: 304.2ºC
• Density: 1.3 g/cm³
• Appearance: White or almost white crystalline powder
• Storage: 4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light).
• Exact Mass: 434.21000
• Hazard Statements: Xi:Irritant
• Safety Description: S36/37
• Shipping: Can be shipped at room temperature, where not in use may vary.
• WGK Germany: 3

Custom Q&A

What is the molecular formula of dexamethasone acetate?

The molecular formula of dexamethasone acetate is C24H31FO6.

What is the molecular weight of dexamethasone acetate?

The molecular weight of dexamethasone acetate is 434.5 g/mol.

What is the IUPAC name of dexamethasone acetate?

The IUPAC name of dexamethasone acetate is [2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate.

What is the CAS number of dexamethasone acetate?

The CAS number of dexamethasone acetate is 1177-87-3.

What are the synonyms of dexamethasone acetate?

The synonyms of dexamethasone acetate include DEXAMETHASONE ACETATE, Dexamethasone 21-acetate, Decadronal, and Decadron-LA.

What is the common name for dexamethasone acetate?

The common name for dexamethasone acetate is decadron.

What is the chemical classification of dexamethasone acetate?

Dexamethasone acetate is classified as a corticosteroid hormone.

How does dexamethasone acetate function in the body?

Dexamethasone acetate is a synthetic adrenal corticosteroid with potent anti-inflammatory properties. It binds to specific nuclear steroid receptors, interferes with NF-kB activation and apoptotic pathways, and lacks the salt-retaining properties of other related adrenal hormones.

What is the clinical application of dexamethasone acetate?

Dexamethasone acetate has been administered for the treatment of inflammatory respiratory, allergic, autoimmune, and other conditions. It is used for a variety of inflammatory conditions and has also been a drug of interest in the treatment of COVID-19.

What were the findings of the clinical trial involving dexamethasone acetate and COVID-19?

In a clinical trial called RECOVERY, it was reported that dexamethasone acetate reduced COVID-19 deaths by approximately one-fifth and one-third in patients on oxygen therapy and mechanical ventilation, respectively. It was recommended as a life-saving treatment for COVID-19 patients experiencing severe respiratory symptoms.