Dehydrocorydaline

• CAS: 30045-16-0
• Catalog Number: ACM30045160
• Category: Inhibitors
• Molecular Weight: 366.4
• Description: Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.
• Synonyms: 13-Methylpalmatine
• InChI: InChI=1S/C22H24NO4/c1-13-15-6-7-18(24-2)22(27-5)17(15)12-23-9-8-14-10-19(25-3)20(26-4)11-16(14)21(13)23/h6-7,10-12H,8-9H2,1-5H3/q+1
• InChI Key: RFKQJTRWODZPHF-UHFFFAOYSA-N
• Melting Point: 170-173 °C
• Complexity: 503
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 0
• Exact Mass: 366.17053325
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 0
• Monoisotopic Mass: 366.17053325
• Physical State: Powder
• Rotatable Bond Count: 4
• Topological Polar Surface Area: 40.8 Ų

Custom Q&A

What is the chemical name of Dehydrocorydaline?

The chemical name of Dehydrocorydaline is 5,6-Dihydro-2,3,9,10-tetramethoxy-13-methyl-dibenzo[a,g]quinolizinium.

What are some synonyms of Dehydrocorydaline?

Some synonyms of Dehydrocorydaline are 13-Methylpalmatine, aldehydeocorydaline, and Dibenzo[a,g]quinolizinium.

What is the CAS number of Dehydrocorydaline?

The CAS number of Dehydrocorydaline is 30045-16-0.

In what form does Dehydrocorydaline exist?

Dehydrocorydaline exists in crystalline form.

What is the melting point of Dehydrocorydaline?

The melting point of Dehydrocorydaline is 170-173℃.

From which plant is Dehydrocorydaline derived?

Dehydrocorydaline is derived from Corydalis Corydalis, Yuanhu.

What are the biological activities of Dehydrocorydaline?

Dehydrocorydaline has anti-inflammatory, anti-cancer, and potent antimalarial effects.

How does Dehydrocorydaline affect the growth of MCF-7 cells in vitro?

Dehydrocorydaline inhibits the growth of MCF-7 cells in a dose-dependent manner and induces activation of caspase-7, -8, and the cleavage of PARP.

What is the LD50 of Dehydrocorydaline in mice following oral administration?

The LD50 of Dehydrocorydaline in mice following oral administration is about 277.5±19.0 mg/kg body weight.

What are some target proteins of Dehydrocorydaline?

Some target proteins of Dehydrocorydaline are Bcl-2, Bax, Caspase-7, Caspase-8, and PARP.