Dehydroandrographolide succinate

• CAS: 786593-06-4
• Catalog Number: ACM786593064
• Category: Inhibitors
• Molecular Weight: 532.582
• Molecular Formula: C₂₈H₃₆O₁₀
• Description: Dehydroandrographolide succinate, extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect.
• Synonyms: UNII-0X50BP49M1, Dehydroandrographolide succinate, 14-Deoxy-11,12-didehydroandrographolide bis(hemisuccinate), 786593-06-4, Butanedioic acid, 1-(((1R,2R,4aR,5R,8aS)-2-(3-carboxy-1-oxopropoxy)-5-((1E)-2-(2,5-dihydro-2-oxo-3-furanyl)ethenyl)decahydro-1,4a-dimethyl-6-methylene-1-naphthalenyl)methyl) ester
• IUPAC Name: 4-[[(1R,2R,4aS,5R,8aS)-2-(3-carboxypropanoyloxy)-1,4a-dimethyl-6-methylidene-5-[(2E)-2-(2-oxofuran-3-ylidene)ethyl]-3,4,5,7,8,8a-hexahydro-2H-naphthalen-1-yl]methoxy]-4-oxobutanoic acid
• Canonical SMILES: CC12CCC(C(C1CCC(=C)C2C=CC3=CCOC3=O)(C)COC(=O)CCC(=O)O)OC(=O)CCC(=O)O
• InChI Key: RVMAILYTHYEMAC-AETYNEKVSA-N
• Boiling Point: 733.8ºC at 760 mmHg
• Melting Point: 136-138ºC
• Flash Point: 239.1ºC
• Density: 1.29g/cm³
• Appearance: Solid
• Storage: 4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light).
• Exact Mass: 532.23100
• H-Bond Acceptor: 10
• H-Bond Donor: 2
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Source: PlantsAcanthaceaeAndrographis paniculata (Burm. F.) Nees

Synthetic Use

Upstream Synthesis Route 1

• 108-30-5

• 786593-06-4

Reference: [1] Patent: CN107857747, 2018, A, . Location in patent: Paragraph 0043-0045; 0048-0050; 0053-0055; 0058-0060

Upstream Synthesis Route 2

• 108-30-5
• 142037-79-4

• 110-15-6
• 786593-06-4

Reference: [1] Synthetic Communications, 2009, vol. 39, # 19, p. 3444 - 3452

Upstream Synthesis Route 3

• 108-30-5
• 5508-58-7

• 110-15-6
• 786593-06-4

Reference: [1]Location in patent: experimental part
Luo, Xin-Feng; He, Ling; Yin, Hai-Bin; Zheng, Hu; Bei, Di; Deng, Jin-Jin; Huang, Wen-Cai
[Synthetic Communications, 2009, vol. 39, # 19, p. 3444 - 3452]

Upstream Synthesis Route 4

• 869807-57-8
• 108-30-5

• 786593-06-4

Reference: [1]Current Patent Assignee: GUANGZHOU PERSON PHARMACEUTICAL - CN107857747, 2018, A
Location in patent: Paragraph 0043-0045; 0048-0050; 0053-0055; 0058-0060