D-Pantethine

• CAS: 16816-67-4
• Catalog Number: ACM16816674
• Category: Main Products
• Molecular Weight: 554.72
• Molecular Formula: C22H42N4O8S2
• Synonyms: D-Bis-pantothenyl-b-aminoethyl disulfide
• Appearance: viscous liquid

Case Study

Combination of Selenomethionine and D-Pantethine Reduces the Negative Side Effects of Doxorubicin in NL/Ly Lymphoma-Bearing Mice

Panchuk, Rostyslav R., et al. Croatian Medical Journal, 2016, 57(2), 180-192.

The research examined how selenomethionine and D-pantethine reduce damage when combined with doxorubicin for treating mice with NK/Ly lymphoma. Researchers compared survival rates, blood cell counts, liver toxicity levels, glutathione concentrations and glutathione-related enzyme activity between the joint treatment and monotherapy with Dx.
Key Findings
· The combination of D-pantethine (500 mg/kg) and selenomethionine (600 µg/kg) reduced Dx (5 mg/kg) induced leukocytopenia and erythropenia after 14 days of treatment.
· The combination treatment resulted in mice living beyond 60 days compared to their initial survival period of 47-48 days and enhanced their general quality of life. The antioxidants displayed protective effects through their hepatoprotective properties and their ability to modulate the immune system.
· D-pantethine brought acid-soluble and free CoA levels back to normal in tumor-bearing mice livers while selenomethionine restored glutathione peroxidase levels that Dx had lowered. The liver glutathione levels dropped after treatment with both antioxidants despite previous elevation caused by Dx treatment.
· Finally, the antioxidants selenomethionine and D-pantethine reduced Dx's harmful effects on NK/Ly lymphoma-bearing mice and substantially improved chemotherapy effectiveness.

Mechanistic Insights: How Pantethine Affects Membrane Rafts

van Gijsel-Bonnello, Manuel, et al. Journal of Cellular Physiology, 2015, 230(10), 2415-2425.

Pantethine emerges as a naturally occurring low molecular weight thiol which demonstrates extensive functionality across numerous fundamental cellular pathways. Pantethine has gained recognition for its hypolipidemic and hypocholesterolemic effects along with its potential to protect neural functions. This research examined how pantethine affects membrane lipid rafts that serve as platforms for cellular molecules in order to identify a target for blocking inappropriate cellular responses that cause chronic inflammation.
Key Findings
· Researchers examined different T cell types such as a human T cell line alongside circulating effector T cells and rat splenic CD3+ cells to show how pantethine operates through multiple overlapping mechanisms. Membrane cholesterol levels and fatty acid composition of membrane rafts along with chemokine receptor dynamics represent mechanisms that the cell's redox status influences. Pantethine functions to disrupt cell adhesion while simultaneously inhibiting CXCL12-driven migration.
· The mechanisms identified include alterations in: The identified mechanisms consist of CXCL12 binding to target cells together with changes in CXCR4 and CXCR7 receptor dynamics and the regulatory role of cellular redox status in the chemokine system.
· The research used the linker for activation of T cells (LAT) to show how pantethine causes displacement of acylated signaling molecules from lipid rafts resulting in decreased palmitoylation levels. Research showed pantethine managed numerous mechanisms which reduce abnormal T cell activation and migration.

Custom Q&A

What is the PubChem CID of D-Pantethine?

The PubChem CID of D-Pantethine is 452306.

What is the molecular formula of D-Pantethine?

The molecular formula of D-Pantethine is C22H42N4O8S2.

What is the molecular weight of D-Pantethine?

The molecular weight of D-Pantethine is 554.7 g/mol.

How is D-Pantethine synthesized in the body?

D-Pantethine is synthesized in the body from pantothenic acid (vitamin B5) via addition of cysteamine.

What is the role of D-Pantethine in the body?

D-Pantethine has a role as a nutraceutical and a coenzyme. It is functionally related to pantothenic acid.

What is the IUPAC name of D-Pantethine?

The IUPAC name of D-Pantethine is (2R)-N-[3-[2-[2-[3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyldisulfanyl]ethylamino]-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide.

What is the InChIKey of D-Pantethine?

The InChIKey of D-Pantethine is DJWYOLJPSHDSAL-ROUUACIJSA-N.

What is the CAS number of D-Pantethine?

The CAS number of D-Pantethine is 16816-67-4.

What is the ChEBI ID of D-Pantethine?

The ChEBI ID of D-Pantethine is CHEMBL2104786.

What is the XLogP3-AA value of D-Pantethine?

The XLogP3-AA value of D-Pantethine is -2.2.