CUN79177

• CAS: 2270879-17-7
• Catalog Number: ACM2270879177
• Category: Inhibitors
• Molecular Weight: 318.27
• Molecular Formula: C11H9F3N4O2S
• Description: NVP-RXI570, also known as CUN79177 and BRM/BRG1 ATP Inhibitor-1, is an orally Active Inhibitors (IC50=5 nM) of Brahma Homolog (BRM)​/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)​/SMARCA4-​Mutant Cancers. CUN79177 was first reported ion Journal of Medicinal Chemistry (2018), 61(22), 10155-10172.
• Synonyms: BRM/BRG1 ATP Inhibitor-1; CUN79177; CUN79177; CUN-79177; NVP-RXI570; NVP-RXI-570; NVP-RXI 570
• IUPAC Name: 1-[3-(Difluoromethyl)isothiazol-5-yl]-3-[2-fluoro-5-(hydroxymethyl)pyridin-4-yl]urea
• Canonical SMILES: O=C(NC1=CC(F)=NC=C1CO)NC2=CC(C(F)F)=NS2
• InChI: InChI=1S/C11H9F3N4O2S/c12-8-1-6(5(4-19)3-15-8)16-11(20)17-9-2-7(10(13)14)18-21-9/h1-3,10,19H,4H2,(H2,15,16,17,20)
• InChI Key: CKYCAIAVJIFWPE-UHFFFAOYSA-N
• Solubility: To be determined
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Drug Formulation: To be determined
• Elemental Analysis: C, 41.51; H, 2.85; F, 17.91; N, 17.60; O, 10.05; S, 10.07
• Exact Mass: 318.0398
• HS Tariff Code: 2934.99.9001
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).