Boc-Trp(For)-OH

• CAS: 47355-10-2
• Catalog Number: ACM47355102
• Category: Amino Acids
• Molecular Weight: 332.35
• Description: Standard building block for introduction of tryptophan by Boc SPPS. The formyl group is stable to standard high HF cleavage but can be removed by HF containing thiophenol. The formyl group can also be removed with piperidine in DMF prior to HF cleavage.
• Synonyms: Boc-Trp(For)-OH, N-α-t.-Boc-N-in-formyl-L-tryptophan
• InChI: 1S/C17H20N2O5/c1-17(2,3)24-16(23)18-13(15(21)22)8-11-9-19(10-20)14-7-5-4-6-12(11)14/h4-7,9-10,13H,8H2,1-3H3,(H,18,23)(H,21,22)/t13-/m0/s1
• InChI Key: IHXHBYFWSOYYTR-ZDUSSCGKSA-N
• Melting Point: 100 ℃(decomposition)
• Application: Peptide synthesis.
• Assay: ≥98% (TLC)
• Form: Empirical Formula (Hill Notation):; C17H20N2O5
• Functional Group: Boc
• MDL Number: MFCD00065992
• Quality Level: 200
• Reaction Suitability: reaction type: Boc solid-phase peptide synthesis
• Storage Temperature: 15-25℃

Synthetic Use

Upstream Synthesis Route 1

• 24424-99-5
• 74257-18-4

• 47355-10-2

Reference: [1] Organic Syntheses, 1985, vol. 63, p. 160 - 160

Downstream Synthesis Route 1

• 128421-96-5
• 47355-10-2

• 143192-38-5

Reference: [1]Journal of Organic Chemistry,1992,vol. 57,p. 5687 - 5692

Downstream Synthesis Route 2

• 18598-71-5
• 47355-10-2

• 86332-25-4

Reference: [1]Chemical and Pharmaceutical Bulletin,1982,vol. 30,p. 4435 - 4443

Downstream Synthesis Route 3

• 1738-78-9
• 47355-10-2

• 140834-89-5

Reference: [1]Journal of Medicinal Chemistry,1992,vol. 35,p. 2015 - 2025

* For details of the synthesis route, please refer to the original source to ensure accuracy.