BB-83698

• CAS: 325795-25-3
• Catalog Number: ACM325795253
• Category: Inhibitors
• Molecular Weight: 530.67
• Molecular Formula: C28H42N4O6
• Description: BB-83698 is a peptide deformylase inhibitor and potent antimicrobial with excellent activity against streptococci and Moraxella catarrhalis strains.
• Synonyms: BB-83698; BB 83698; BB83698
• IUPAC Name: Cyclopentanepropanamide, N-((1S)-1-((4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)carbonyl)-2,2-dimethylpropyl)-alpha-((formylhydroxyamino)methyl)-, (alphaR)-
• Canonical SMILES: O=C(N[C@H](C(N1CCN(CC2=CC=C(OCO3)C3=C2)CC1)=O)C(C)(C)C)[C@@H](CN(C=O)O)CC4CCCC4
• InChI: InChI=1S/C28H42N4O6/c1-28(2,3)25(29-26(34)22(17-32(36)18-33)14-20-6-4-5-7-20)27(35)31-12-10-30(11-13-31)16-21-8-9-23-24(15-21)38-19-37-23/h8-9,15,18,20,22,25,36H,4-7,10-14,16-17,19H2,1-3H3,(H,29,34)/t22-,25-/m1/s1
• InChI Key: IBEANEPZNLVRRY-RCZVLFRGSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: BB-83698 is a peptide deformylase inhibitor and potent antimicrobial.
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 63.37; H, 7.98; N, 10.56; O, 18.09
• Exact Mass: 530.3104
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: BB-83698 demonstrated potent in vitro activity against all of the strains, regardless of preexisting resistance mechanisms (MICs, 0.06; to 0.25 μg/ml) (Table 1).; Reference: Antimicrob Agents Chemother. 2004 Jan;48(1):80-5. https://pubmed.ncbi.nlm.nih.gov/14693522/
• In Vivo Activity: Mice infected with penicillin-susceptible and macrolide-resistant strain P-6254 (erythromycin MIC, 1,024 μg/ml) had 10-day survival rates of 100% when they were treated with BB-83698 at 80 mg/kg/12 h or 160 mg/kg/24 h starting at 6 h postinfection. Comparator mice treated with erythromycin or azithromycin at 100 mg/kg/12 h had 10-day survival rates of only 30% (Fig. 1B). Treatment with amoxicillin at 5 mg/kg protected 80% of mice.; Reference: Antimicrob Agents Chemother. 2004 Jan;48(1):80-5. https://pubmed.ncbi.nlm.nih.gov/14693522/
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).