AG-7404

• CAS: 343565-99-1
• Catalog Number: ACM343565991
• Category: Inhibitors
• Molecular Weight: 523.55
• Molecular Formula: C26H29N5O7
• Description: AG-7404 is a potent protease inhibitor with Anti-poliovirus activity. AG-7404 was active against all virus with EC50 values ranging from 0.080 to 0.674 μM. AG-7404 was fully active against all V-073-resistant variants, with EC₅₀ values ranging from 0.218 to 0.819 μM, compared to values of 0.202-0.407 μM for the V-073-susceptible parental strains. In vitro drug combination experiments demonstrated synergy between AG-7404 and either V-073 or BTA798, whereas the combination of the two capsid inhibitors acted additively.
• Synonyms: AG-7404; AG 7404; AG7404; V 7404; V-7404; V7404
• IUPAC Name: (S,E)-ethyl 4-((S)-2-(3-(5-methylisoxazole-3-carboxamido)-2-oxopyridin-1(2H)-yl)pent-4-ynamido)-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoate
• Canonical SMILES: O=C(OCC)/C=C/[C@@H](NC([C@@H](N1C=CC=C(NC(C2=NOC(C)=C2)=O)C1=O)CC#C)=O)C[C@H]3C(NCC3)=O
• InChI: InChI=1S/C26H29N5O7/c1-4-7-21(31-13-6-8-19(26(31)36)29-24(34)20-14-16(3)38-30-20)25(35)28-18(9-10-22(32)37-5-2)15-17-11-12-27-23(17)33/h1,6,8-10,13-14,17-18,21H,5,7,11-12,15H2,2-3H3,(H,27,33)(H,28,35)(H,29,34)/b10-9+/t17-,18+,21-/m0/s1
• InChI Key: QCUZOJBYWQPLIN-BNMFZAHFSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: AG-7404 is a potent protease inhibitor with Anti-poliovirus activity.
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 59.65; H, 5.58; N, 13.38; O, 21.39
• Exact Mass: 523.2067
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: The spectrum of AG-7404 and BTA798 activity against a panel of 45 polioviruses was evaluated in a cell culture CPE assay. AG-7404 was active against all viruses in this panel, with EC50 values ranging from 0.080 to 0.674 μM. Ninety percent of all polioviruses tested were inhibited by AG-7404 at an EC50 value of ⩽0.446 μM (MIC90 = 0.446 μM) and by BTA798 at an EC50 value of ⩽0.236 μM (MIC90 = 0.236 μM).; Reference: Antiviral Res. 2013 May;98(2):186-91. https://pubmed.ncbi.nlm.nih.gov/23499651/
• In Vivo Activity: TBD
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).