Asperosaponin Vi

• CAS: 39524-08-8
• Catalog Number: ACM39524088
• Category: Inhibitors
• Molecular Weight: 929.10
• Molecular Formula: C47H76O18
• Description: Asperosaponin VI, A saponin component from Dipsacus asper, induces osteoblast differentiation through BMP-2/p38 and ERK1/2 pathway. Asperosaponin Ⅵ inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB.
• IUPAC Name: [(3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl] (6aS,9R)-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-10-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
• Canonical SMILES: CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)CO)OC6C(C(C(CO6)O)O)O)C)C)C2C1)C)C(=O)OC7C(C(C(C(O7)COC8C(C(C(C(O8)CO)O)O)O)O)O)O)C
• InChI Key: CCRXMHCQWYVXTE-VKJQVCSQSA-N
• Appearance: White powder

Synthetic Use

Upstream Synthesis Route 1

• 97240-03-4

• 39524-08-8

Reference: [1] Chemical and Pharmaceutical Bulletin, 1985, vol. 33, # 8, p. 3473 - 3478

Upstream Synthesis Route 2

• 14216-03-6

• 17184-21-3
• 39524-08-8
• 99624-66-5
• 27013-91-8

Reference: [1] Chemical and Pharmaceutical Bulletin, 1985, vol. 33, # 8, p. 3473 - 3478

Upstream Synthesis Route 3

• 12672-45-6

• 39524-08-8

Reference: [1] Phytochemistry, 1993, vol. 34, # 5, p. 1389 - 1394

Upstream Synthesis Route 4

• 14216-03-6

• 17184-21-3
• 39524-08-8
• 99624-66-5
• 27013-91-8

Reference: [1]Chemical and Pharmaceutical Bulletin,1985,vol. 33,p. 3473 - 3478

Downstream Synthesis Route 1

• 39524-08-8

• 536-11-8
• 17184-21-3

Reference: [1]Liebigs Annalen der Chemie,1992,p. 453 - 460

Downstream Synthesis Route 2

• 39524-08-8

• 17184-21-3

Reference: [1]Phytochemistry,1993,vol. 34,p. 1389 - 1394
[2]Liebigs Annalen der Chemie,1986,vol. 1986,p. 638 - 646

* For details of the synthesis route, please refer to the original source to ensure accuracy.