Structure

Asperosaponin Vi

CAS
39524-08-8
Catalog Number
ACM39524088
Category
Inhibitors
Molecular Weight
929.10
Molecular Formula
C47H76O18

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Specification

Description
Asperosaponin VI, A saponin component from Dipsacus asper, induces osteoblast differentiation through BMP-2/p38 and ERK1/2 pathway. Asperosaponin Ⅵ inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB.
IUPAC Name
[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl] (6aS,9R)-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-10-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
Canonical SMILES
CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)CO)OC6C(C(C(CO6)O)O)O)C)C)C2C1)C)C(=O)OC7C(C(C(C(O7)COC8C(C(C(C(O8)CO)O)O)O)O)O)O)C
InChI Key
CCRXMHCQWYVXTE-VKJQVCSQSA-N
Appearance
White powder

Upstream Synthesis Route 1

  • 97240-03-4
  • 39524-08-8

Reference: [1] Chemical and Pharmaceutical Bulletin, 1985, vol. 33, # 8, p. 3473 - 3478

Upstream Synthesis Route 2

  • 14216-03-6
  • 17184-21-3
  • 39524-08-8
  • 99624-66-5
  • 27013-91-8

Reference: [1] Chemical and Pharmaceutical Bulletin, 1985, vol. 33, # 8, p. 3473 - 3478

Upstream Synthesis Route 3

  • 12672-45-6
  • 39524-08-8

Reference: [1] Phytochemistry, 1993, vol. 34, # 5, p. 1389 - 1394

Upstream Synthesis Route 4

  • 14216-03-6
  • 17184-21-3
  • 39524-08-8
  • 99624-66-5
  • 27013-91-8

Reference: [1]Chemical and Pharmaceutical Bulletin,1985,vol. 33,p. 3473 - 3478

Downstream Synthesis Route 1

  • 39524-08-8
  • 536-11-8
  • 17184-21-3

Reference: [1]Liebigs Annalen der Chemie,1992,p. 453 - 460

Downstream Synthesis Route 2

  • 39524-08-8
  • 17184-21-3

Reference: [1]Phytochemistry,1993,vol. 34,p. 1389 - 1394
[2]Liebigs Annalen der Chemie,1986,vol. 1986,p. 638 - 646

* For details of the synthesis route, please refer to the original source to ensure accuracy.

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