4-Aminosalicylic acid

• CAS: 65-49-6
• Catalog Number: ACM65496-2
• Category: Amino Acids
• Molecular Weight: 153.14
• Molecular Formula: H2NC6H3-2-(OH)CO2H
• Synonyms: 4-Amino-2-hydroxybenzoic acid, PAS
• Canonical SMILES: Nc1ccc(C(O)=O)c(O)c1
• InChI: 1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)
• InChI Key: WUBBRNOQWQTFEX-UHFFFAOYSA-N
• Melting Point: 135-145 ℃(lit.)
• Application: 4-Aminosalicylic acid (4-ASA) can be used in the synthesis of:; Azo derivatives of 4-ASA with anti-inflammatory effects.; Ammonium 4-aminosalicylate salt polymorphs which are used as pharmaceutical ingredients.; Salicylic acid-triazole analogs which are used as quorum sensing inhibitors against Pseudomonas aeruginosa.
• Assay: 0.99
• Beilstein: 473071
• Color: white to beige
• EC Number: 200-613-5
• Form: powder
• Gene Information: human PTPN1(5770)
• MDL Number: MFCD00007789
• NACRES: NA.22
• PubChem ID: 24891299
• Quality Level: 200
• Reaction Suitability: reaction type: solution phase peptide synthesis
• Storage Temperature: 2-8℃

Synthetic Use

Upstream Synthesis Route 1

• 619-19-2

• 65-49-6

Reference: [1] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006, vol. 45, # 1, p. 297 - 301

Upstream Synthesis Route 2

• 591-27-5

• 65-49-6

Reference: [1] Journal of Organic Chemistry, 1958, vol. 23, p. 1422
[2] DRP/DRBP Org.Chem.,
[3] DRP/DRBP Org.Chem.,
[4] Monatshefte fuer Chemie, 1949, vol. 80, p. 197,199
[5] Organic Letters, 2012, vol. 14, # 8, p. 1974 - 1977

Upstream Synthesis Route 3

• 17980-39-1

• 65-49-6

Reference: [1] Patent: US2013/96249, 2013, A1, . Location in patent: Page/Page column

Upstream Synthesis Route 4

• 619-19-2

• 65-49-6

Reference: [1]Srinivasa; Abiraj; Gowda, D. Channe
[Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006, vol. 45, # 1, p. 297 - 301]