Alpha-Mangostin

• CAS: 6147-11-1
• Catalog Number: ACM6147111-1
• Category: Inhibitors
• Molecular Weight: 410.46
• Molecular Formula: C24H26O6
• Description: Alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM.
• Synonyms: Α-Mangostin
• Canonical SMILES: O=C1C2=C(OC3=C1C(C/C=C(C)\C)=C(OC)C(O)=C3)C=C(O)C(C/C=C(C)\C)=C2O
• Appearance: Solid
• Storage: Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Source: Plantsother families

Synthetic Use

Downstream Synthesis Route 1

• 6147-11-1

• 182051-07-6

Reference: [1]Nippon Kagaku Kaishi/Journal of the Chemical Society of Japan,1931,vol. 52,p. 548,552
Bulletin of the Chemical Society of Japan,1932,vol. 7,p. 1,7

Downstream Synthesis Route 2

• 6147-11-1

• 182317-42-6

Reference: [1]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 2062 - 2065

Downstream Synthesis Route 3

• 6147-11-1

• 26063-96-7
• 19275-46-8
• 112649-47-5

Reference: [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1987,vol. 26,p. 281 - 282

* For details of the synthesis route, please refer to the original source to ensure accuracy.