Alcaftadine

• CAS: 147084-10-4
• Catalog Number: ACM147084104
• Category: Main Products
• Molecular Weight: 307.39
• Molecular Formula: C₁₉H₂₁N₃O
• Synonyms: 11-(1-methylpiperidin-4-ylidene)-5,6-dihydroimidazo[2,1-b][3]benzazepine-3-carbaldehyde; UNII-7Z8O94ECSX; alcaftadinum; Vilasta; Lastacaft; Alcaftadine; alcaftadina
• IUPAC Name: 11-(1-methylpiperidin-4-ylidene)-5,6-dihydroimidazo[2,1-b][3]benzazepine-3-carbaldehyde
• Canonical SMILES: CN1CCC(=C2C3=CC=CC=C3CCN4C2=NC=C4C=O)CC1
• InChI Key: MWTBKTRZPHJQLH-UHFFFAOYSA-N
• Exact Mass: 307.16800

Case Study

Comparative Efficacy of Alcaftadine for the Treatment of Allergic Conjunctivitis

Xuan J, et al. Revue Française d'Allergologie, 63(6), 103688.

Recent studies, including a comprehensive meta-analysis, have investigated Alcaftadine's efficacy in comparison to olopatadine, another antihistamine, with an emphasis on ocular symptoms and conjunctival hyperemia.
The meta-analysis incorporated 10 randomized controlled trials (RCTs), comparing the outcomes of alcaftadine versus olopatadine in patients suffering from allergic conjunctivitis. Ocular symptoms score and conjunctival hyperemia score were evaluated on days 3, 7, and 14, providing a temporal perspective on the efficacy of both drugs.
Results demonstrated that while alcaftadine and olopatadine produced comparable results in the early stages (days 3 and 7), alcaftadine exhibited a superior reduction in ocular symptoms by day 14 (SMD = -0.33; 95% CI = -0.51 to -0.15; P = 0.0004). This indicates that alcaftadine may offer prolonged relief for patients. Moreover, alcaftadine showed a significant improvement in conjunctival hyperemia on day 3, indicating its rapid anti-inflammatory effects.
Importantly, the incidence of ocular adverse events between the two interventions was statistically similar (OR = 1.37; 95% CI = 0.12 to 16.12; P = 0.80), suggesting that alcaftadine presents no additional safety concerns relative to olopatadine.
This analysis highlights the extended efficacy of alcaftadine, particularly in reducing ocular symptoms over a 14-day period. Its prompt impact on conjunctival hyperemia further suggests that it is a potent alternative to olopatadine for allergic conjunctivitis treatment.

Custom Q&A

What is the molecular formula of Alcaftadine?

The molecular formula of Alcaftadine is C19H21N3O.

What are the synonyms for Alcaftadine?

The synonyms for Alcaftadine include Lastacaft, R 89674, Alcaftadine [USAN:INN], and more.

What is the chemical safety information for Alcaftadine?

The chemical safety information for Alcaftadine is not provided in the reference.

What is the IUPAC name of Alcaftadine?

The IUPAC name of Alcaftadine is 11-(1-methylpiperidin-4-ylidene)-5,6-dihydroimidazo[2,1-b][3]benzazepine-3-carbaldehyde.

Is Alcaftadine classified as an antihistamine?

Yes, Alcaftadine is classified as an antihistamine.

What is the role of Alcaftadine?

The role of Alcaftadine is as a H1-receptor antagonist and an anti-allergic agent.

Does Alcaftadine have any other chemical names?

Yes, Alcaftadine has other chemical names such as Lastacaft (TN), R89674, and Alcaftadine [USAN:INN].

Is Alcaftadine a tertiary amino compound?

Yes, Alcaftadine is a tertiary amino compound.

What is the PubChem ID of Alcaftadine?

The PubChem ID of Alcaftadine is not provided in the reference.

What is the create date of Alcaftadine?

The create date of Alcaftadine is December 4, 2007.