(1R,2R)-N-Tert.-butoxycarbonylcyclohexane-1,2-diamine

• CAS: 146504-07-6
• Catalog Number: ACM146504076
• Category: Main Products
• Molecular Weight: 214.30
• Molecular Formula: C₁₁H₂₂N₂O₂
• Synonyms: trans-2-morpholinocyclohexanol
• IUPAC Name: tert-butylN-[(1R,2R)-2-aminocyclohexyl]carbamate
• Canonical SMILES: CC(C)(C)OC(=O)NC1CCCCC1N
• InChI Key: AKVIZYGPJIWKOS-RKDXNWHRSA-N
• Boiling Point: 322.1ºC at 760 mmHg
• Flash Point: 148.6ºC
• Density: 1.02 g/cm³
• Exact Mass: 214.16800
• Hazard Statements: C: Corrosive
• Safety Description: S26

Synthetic Use

Upstream Synthesis Route 1

• 24424-99-5
• 20439-47-8

• 146504-07-6

Reference: [1] Journal of the Chemical Society, Dalton Transactions, 2001, # 14, p. 2188 - 2198

Upstream Synthesis Route 2

• 315179-47-6

• 146504-07-6

Reference: [1] Journal of Organic Chemistry, 2000, vol. 65, # 23, p. 7807 - 7813

Upstream Synthesis Route 3

• 24424-99-5
• 20439-47-8

• 146504-07-6

Reference: [1] Synlett, 2017, vol. 28, # 11, p. 1278 - 1281

Upstream Synthesis Route 4

• 24424-99-5
• 20439-47-8

• 146504-07-6

Reference: [1]Uppadine; Keene; Beer
[Journal of the Chemical Society, Dalton Transactions, 2001, # 14, p. 2188 - 2198]

Downstream Synthesis Route 1

• 17261-28-8
• 146504-07-6

• 315179-52-3

Reference: [1]Pálvölgyi, Ádám Márk; Schnürch, Michael; Bica-Schröder, Katharina
[Tetrahedron, 2020, vol. 76, # 51]
[2]Liu, Weigang; Pan, Hongjie; Tian, Hua; Shi, Yian
[Organic Letters, 2015, vol. 17, # 16, p. 3956 - 3959]
[3]Current Patent Assignee: Institute of Chemistry (in: CAS); CHINESE ACADEMY OF SCIENCES - CN105017172, 2017, B
Location in patent: Paragraph 0042; 0043; 0045
[4]Kim, Young Kook; Lee, Seok Jong; Ahn, Kyo Han
[Journal of Organic Chemistry, 2000, vol. 65, # 23, p. 7807 - 7813]

Downstream Synthesis Route 2

• 146504-07-6
• 5659-93-8

• 323187-46-8

Reference: [1]Marson; Schwarz
[Tetrahedron Letters, 2000, vol. 41, # 46, p. 8999 - 9003]
[2]Reiersølmoen, Ann Christin; Solvi, Thomas N.; Fiksdahl, Anne
[Beilstein Journal of Organic Chemistry, 2021, vol. 17, p. 186 - 190]

* For details of the synthesis route, please refer to the original source to ensure accuracy.