AH-7614

• CAS: 6326-06-3
• Catalog Number: ACM6326063
• Category: Antagonists
• Molecular Weight: 351.42
• Molecular Formula: C20H17NO3S
• Description: AH-7614 is a selective free fatty acid receptor 4 (FFA4/GPR120) antagonist.
• Synonyms: AH-7614; AH 7614; AH7614
• IUPAC Name: 4-Methyl-N-9H-xanthen-9-yl-benzenesulfonamide
• Canonical SMILES: O=S(C1=CC=C(C)C=C1)(NC2C3=C(OC4=C2C=CC=C4)C=CC=C3)=O
• InChI: InChI=1S/C20H17NO3S/c1-14-10-12-15(13-11-14)25(22,23)21-20-16-6-2-4-8-18(16)24-19-9-5-3-7-17(19)20/h2-13,20-21H,1H3
• InChI Key: OZCQEUZTOAAWDK-UHFFFAOYSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: AH-7614 is a potent and selective FFA4 (GPR120) antagonist, with pIC50s of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively, as well as has selectivity for FFA4 over FFA1 (pIC50<4.6).
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 68.36; H, 4.88; N, 3.99; O, 13.66; S, 9.12
• Exact Mass: 351.0929
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: To elucidate the mechanism underlying the inhibitory effect of DHA on cerulein-induced zymogen activation via the GPR120 and GPR40 signaling pathway, we investigated whether a GPR120 antagonist AH-7614 and a GPR40 antagonist DC260126 could suppress this inhibitory effect of DHA. As shown in Fig. Fig.4,4, cerulein stimulation increased zymogen activation, and this was inhibited by DHA. However, AH-7614 suppressed the inhibitory effect of DHA on cerulein-induced zymogen activation.; Reference: Genes Nutr. 2020 Mar 23;15(1):6. https://pubmed.ncbi.nlm.nih.gov/32293245/
• In Vivo Activity: To further confirm the requirement of GPR120 and PPARγ in the regulation of IL-1β and NGF production, the antagonists of GPR120 and PPARγ were used in infarcted rats. AH-7614 reversed the attenuated levels of IL-1β levels and NGF compared with EPA or DHA alone, implying that GPR120 is a downstream molecule of ω-3 PUFAs. The relation between both signaling pathways of GPR120 and PPARγ was also assessed. A significant decrease in PPARγ was observed in infarcted hearts infused with a GPR120 antagonist, AH-7614.; Reference: J Nutr Biochem. 2022 Feb 1;103:108950. https://pubmed.ncbi.nlm.nih.gov/35121022/
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).