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Structure

N-(3-Aminopropyl)-N-dodecylpropane-1,3-diamine

CAS
2372-82-9
Catalog Number
ACM2372829
Category
Main Products
Molecular Weight
299.53824
Molecular Formula
C18H41N3

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Specification

Synonyms
N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine;LAURYLAMINE DIPROPYLENEDIAMINE;Bis(aminopropyl)laurylamine;1,3-Propanediamine, N-(3-aminopropyl)-N-dodecyl-;LONZABAC12.100;N-3-AMINOPROPYL-N-DODECYL-1,3-PROPANEDIAMINE;N-(3-Aminopropyl)-N-dodecylpropan-1,3-diamin;3-Propanediamine, N-(3-aminopropyl)-N-dodecyl-1
IUPAC Name
N'-(3-aminopropyl)-N'-dodecylpropane-1,3-diamine
Canonical SMILES
CCCCCCCCCCCCN(CCCN)CCCN
InChI Key
NYNKJVPRTLBJNQ-UHFFFAOYSA-N
Boiling Point
386.1ºC at 760mmHg
Flash Point
184.5ºC
Density
0.880
Appearance
colorless or light yellow transparent liquid
EC Number
219-145-8
Exact Mass
299.33000
Packing Group
III

Toxicological evaluation of N-(3-Aminopropyl)-N-dodecylpropane-1,3-diamine

Studies that investigated the effects of N'-(3-aminopropyl)-N'-dodecylpropane-1,3-diamine after repeated oral administration Hartwig, A., Michael Arand, and MAK Commission. The MAK Collection for Occupational Health and Safety 8.1 (2023): Doc011.

N'-(3-Aminopropyl)-N'-dodecylpropane-1,3-diamine [2372-82-9] was evaluated and maximum concentrations (MAK values) were derived for workplaces, considering all toxicological endpoints. The key effects were cardiomyocyte degeneration and lymphohistiocytic infiltration in skeletal muscle of male rats. No NOAELs could be derived for these effects. The LOAEL was 4 mg/kg bw. Extrapolating the NAEL to 1.3 mg/kg bw yielded a MAK value of 0.05 mg/m3 for the inhalable fraction. The derivation of the MAK value is conservative, as the determined oral absorption is very low and for inhalation absorption, a default value of 100% was assumed due to the lack of experimental data. N'-(3-aminopropyl)-N'-dodecylpropane-1,3-diamine is basic and therefore corrosive to rabbit skin, so an irritation potential to the respiratory tract must be assumed. No inhalation studies are available. Compared to several primary, secondary and tertiary amines with MAK values between 1 and 13 mg/m, N'-(3-aminopropyl)-N'-dodecylpropane-1,3-diamine has almost the same or lower basicity. Therefore, a MAK value of 0.05 mg/m should prevent local irritation effects. Since the critical effects are systemic, the substance is classified in Peak Limit Category II. Since the half-life in the blood is at least 28.5 hours, an offset factor of 8 is set. The NOAELs for developmental toxicity in rats and rabbits are 22.5 and 9 mg/kg bw and day, respectively, which can be scaled to concentrations of 1 and 0.66 mg/m2 in the workplace. Therefore, when MAK values are observed and the substance is classified as pregnancy risk group C, there is no reason to fear damage to the embryo or fetus. N'-(3-aminopropyl)-N'-dodecylpropane-1,3-diamine is not genotoxic or carcinogenic. Due to its corrosive properties, the potential for human contact sensitization cannot be clearly assessed. The substance is not a contact sensitizer for guinea pigs. Skin contact is not expected to significantly cause systemic toxicity.
When rats were given doses of 20 mg/kg body weight and above in the diet for 13 weeks, effects on the kidneys were observed, such as degeneration and necrosis of the tubular epithelium, dilation of the tubules with flattened epithelium and increased tubular basophils. In addition, there were enlarged mesenteric lymph nodes and foamy macrophages. At dose levels of 8 mg/kg body weight and day and above, the species was exposed to the substance in the diet for 52 weeks, and the incidence of lymphohistiocytic myocarditis and lymphohistiocytic infiltration in the skeletal muscle of males and alveolar histiocytosis in the lungs of females was also increased. After 104 weeks of administration of the diet, a dose-dependent increase in the incidence and severity of cardiomyocyte degeneration and skeletal muscle lymphohistiocytic infiltration was observed in male rats at doses of 4 mg/kg bw per day and more than 4 mg/day. In female dogs, after 13 weeks of administration in the diet, the activities of aspartase and alanine aminotransferase in plasma increased at 20 mg/kg bw per day and more than 4 mg/day.

Analysis of N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine in dairy products

Analysis of N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine in dairy products Slimani, Kahina, et al. Food chemistry 262 (2018): 168-177.

A novel and robust method for the quantification of N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine residue levels in dairy products using ion-pair reversed-phase liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been developed and fully validated. Sample extraction was performed by salting-out technique using acetonitrile and sodium chloride. For LC-MS/MS, positive electrospray ionization (ESI+) was used to detect the analytes and two multiple reaction monitoring (MRM) transitions were monitored. The method was validated in the range of 5-150 μg kg using the total error method. Therefore, the performance criteria of the method were evaluated. The relative standard deviations for trueness and precision were below 10%; 5 µg kg was excluded for hard pressed cheese for precision. The limits of quantification (LOQ) were approximately 5-7 µg kg, depending on the matrix of interest. The method was successfully used to accurately quantify N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine in 146 dairy products with a maximum contamination level of 225 μg cheese.
Stock solutions of N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine (97%) (referred to as "TA") and isotopically labeled internal standard (> 98%) (referred to as "TA-d") were prepared in HPLC-grade acetonitrile at a concentration of 1 g Lin. Intermediate and working standard solutions were obtained by serial dilution of the standard stock solutions using a mixture of acetonitrile/water (50:50; v/v) and 1% formic acid (v/v). For the internal standard, 1 mg L dilution solutions were prepared from the stock solutions in the same solvent mixture and added before extraction. All prepared solutions were stored at 4°C. The stability of the standard stock solutions was determined to be satisfactory for at least one year. Chromatographic separation was performed using an ultra-high pressure liquid chromatography (UHPLC) system equipped with an autosampler regulated to +10 °C and a column oven maintained at +25 °C. TA was separated at 0 flow rate for 4 mL. The sample extract (10 μL) was injected into the column and the TA was eluted using a binary gradient for 6 min. The mobile phase consisted of water (A) and acetonitrile (B), both containing 25 mM HFBA and 1% formic acid (v/v). The gradient conditions were as follows: linear gradient from 20% to 80% of eluent B from 0 to 3 min; followed by a rapid linear ramp to 20% of eluent B in 0.5 min; a hold of 2.5 min to re-equilibrate the system before the next injection.

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